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Int. J. Mol. Sci. 2012, 13(12), 16053-16064; doi:10.3390/ijms131216053

MiR-218 Impairs Tumor Growth and Increases Chemo-Sensitivity to Cisplatin in Cervical Cancer

1,†
,
1,†
and
2,*
1
Department of Gynecology, Xin Hua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, 1665 Kongjiang Road, Shanghai 200092, China
2
Department of Gynecology and Obstetrics, Changhai Hospital, Second Military Medical University, 168 Changhai Road, Shanghai 200433, China
These authors contributed equally to this work.
*
Author to whom correspondence should be addressed.
Received: 28 August 2012 / Revised: 15 October 2012 / Accepted: 25 October 2012 / Published: 28 November 2012
(This article belongs to the Section Biochemistry, Molecular Biology and Biophysics)
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Abstract

MicroRNAs are noncoding RNA molecules of 18–25 nucleotides that regulate gene expression at the post-transcriptional levels. Recent data revealed that miR-218 played key roles in tumor metastasis. Here, we described the regulation and function of miR-218 in cervical cancer. Overexpression of miR-218 reduced the proliferation of the human cervical cancer cell line HeLa and induced cell apoptosis through the AKT-mTOR signaling pathway. In addition, it forced expression of miR-218 suppressed tumor growth in the orthotopic mouse model of HeLa cells. Furthermore, miR-218 increased chemosensitivity to cisplatin (CDDP) in vitro. Our results indicated that targeting miR-218 may provide a strategy for blocking the development of cervical cancer. View Full-Text
Keywords: miR-218; cervical cancer; HeLa; cisplatin miR-218; cervical cancer; HeLa; cisplatin
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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Li, J.; Ping, Z.; Ning, H. MiR-218 Impairs Tumor Growth and Increases Chemo-Sensitivity to Cisplatin in Cervical Cancer. Int. J. Mol. Sci. 2012, 13, 16053-16064.

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