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Int. J. Mol. Sci. 2012, 13(12), 16373-16386; doi:10.3390/ijms131216373

Integration of DNA Damage and Repair with Murine Double-Minute 2 (Mdm2) in Tumorigenesis

Department of Pediatrics, Herman B Wells Center for Pediatrics Research, 1044 West Walnut Street, Indianapolis, IN 46202, USA
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Received: 27 September 2012 / Revised: 27 November 2012 / Accepted: 27 November 2012 / Published: 3 December 2012
(This article belongs to the Special Issue DNA Damage and Repair in Degenerative Diseases)
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Abstract

The alteration of tumorigenic pathways leading to cancer is a degenerative disease process typically involving inactivation of tumor suppressor proteins and hyperactivation of oncogenes. One such oncogenic protein product is the murine double-minute 2, or Mdm2. While, Mdm2 has been primarily associated as the negative regulator of the p53 tumor suppressor protein there are many p53-independent roles demonstrated for this oncogene. DNA damage and chemotherapeutic agents are known to activate Mdm2 and DNA repair pathways. There are five primary DNA repair pathways involved in the maintenance of genomic integrity: Nucleotide excision repair (NER), Base excision repair (BER), Mismatch repair (MMR), Non-homologous end joining (NHEJ) and homologous recombination (HR). In this review, we will briefly describe these pathways and also delineate the functional interaction of Mdm2 with multiple DNA repair proteins. We will illustrate the importance of these interactions with Mdm2 and discuss how this is important for tumor progression, cellular proliferation in cancer. View Full-Text
Keywords: base excision repair; cancer; homologous recombination; mismatch repair; murine double minute-2; non-homologous end joining; nucleotide excision repair base excision repair; cancer; homologous recombination; mismatch repair; murine double minute-2; non-homologous end joining; nucleotide excision repair
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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MDPI and ACS Style

Lehman, J.A.; Mayo, L.D. Integration of DNA Damage and Repair with Murine Double-Minute 2 (Mdm2) in Tumorigenesis. Int. J. Mol. Sci. 2012, 13, 16373-16386.

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