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Int. J. Mol. Sci. 2012, 13(9), 11071-11084; doi:10.3390/ijms130911071

The Dual Role of Inflammation in Colon Carcinogenesis

Department of Systems Medicine, University of Rome “Tor Vergata”, Via Montpellier 1, Rome 00133, Italy
Author to whom correspondence should be addressed.
Received: 1 August 2012 / Revised: 28 August 2012 / Accepted: 28 August 2012 / Published: 6 September 2012
(This article belongs to the Special Issue Advances in Molecular Oncology (special issue))
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Chronic inflammation characterizing patients with inflammatory bowel disease (IBD) represents a major risk factor for the development of colorectal cancer. Mechanisms underlying this neoplastic transformation are not fully understood though studies in experimental models of colon carcinogenesis suggest that inflammatory cell-derived cytokines either directly or indirectly stimulate the uncontrolled growth of cancer cells. Nevertheless, under specific inflammatory conditions, immune cells can boost an anti-tumor immune response with the down-stream effect of eliminating dysplastic and cancerous cells. This review outlines the beneficial and detrimental role of inflammation in colon carcinogenesis. View Full-Text
Keywords: colitis-associated colon cancer; IBD; ulcerative colitis; AOM + DSS; tumor immunosurveillance; T cells; inflammation; IL-21; IL-6; IL-17 colitis-associated colon cancer; IBD; ulcerative colitis; AOM + DSS; tumor immunosurveillance; T cells; inflammation; IL-21; IL-6; IL-17
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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Monteleone, G.; Pallone, F.; Stolfi, C. The Dual Role of Inflammation in Colon Carcinogenesis. Int. J. Mol. Sci. 2012, 13, 11071-11084.

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