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Int. J. Mol. Sci. 2013, 14(1), 1455-1476; doi:10.3390/ijms14011455

Role of Oxidative Stress in Refractory Epilepsy: Evidence in Patients and Experimental Models

1
Laboratory of Neurochemistry, National Institute of Pediatrics, 04530, D.F., Mexico
2
Laboratory of Pharmacology, National Institute of Pediatrics, 04530, D.F., Mexico
3
Department of Endocrinology, National Institute of Pediatrics, 04530, D.F., Mexico
4
Unit of Support to Research, National Institute of Rehabilitation, 14389, D.F., Mexico
These authors contributed equally to this work.
*
Authors to whom correspondence should be addressed.
Received: 9 October 2012 / Revised: 6 November 2012 / Accepted: 18 December 2012 / Published: 14 January 2013
(This article belongs to the Special Issue Advances in Free Radicals in Biology and Medicine)
View Full-Text   |   Download PDF [279 KB, 19 June 2014; original version 19 June 2014]

Abstract

Oxidative stress, a state of imbalance in the production of reactive oxygen species and nitrogen, is induced by a wide variety of factors. This biochemical state is associated with systemic diseases, and diseases affecting the central nervous system. Epilepsy is a chronic neurological disorder with refractoriness to drug therapy at about 30%. Currently, experimental evidence supports the involvement of oxidative stress in seizures, in the process of their generation, and in the mechanisms associated with refractoriness to drug therapy. Hence, the aim of this review is to present information in order to facilitate the handling of this evidence and determine the therapeutic impact of the biochemical status for this pathology. View Full-Text
Keywords: oxidative stress; free radicals; refractory epilepsy; pharmacoresistant epilepsy oxidative stress; free radicals; refractory epilepsy; pharmacoresistant epilepsy
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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MDPI and ACS Style

Cardenas-Rodriguez, N.; Huerta-Gertrudis, B.; Rivera-Espinosa, L.; Montesinos-Correa, H.; Bandala, C.; Carmona-Aparicio, L.; Coballase-Urrutia, E. Role of Oxidative Stress in Refractory Epilepsy: Evidence in Patients and Experimental Models. Int. J. Mol. Sci. 2013, 14, 1455-1476.

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