Next Article in Journal
Radical Roles for RAGE in the Pathogenesis of Oxidative Stress in Cardiovascular Diseases and Beyond
Next Article in Special Issue
Role of Hepatic Progenitor Cells in Nonalcoholic Fatty Liver Disease Development: Cellular Cross-Talks and Molecular Networks
Previous Article in Journal / Special Issue
Development of Nonalcoholic Hepatopathy: Contributions of Oxidative Stress and Advanced Glycation End Products
Int. J. Mol. Sci. 2013, 14(10), 19867-19890; doi:10.3390/ijms141019867

Immunological Mechanisms in the Pathophysiology of Non-Alcoholic Steatohepatitis

1,2,* , 1
1 Department of Gastroenterology and Hepatology, University Hospital Antwerp, Wilrijkstraat 10, Edegem 2650, Belgium 2 Department of Basic Medical Sciences, Neuroscience and Sensory Organs, University of Bari, Policlinico, Piazza Giulio Cesare, Bari 70100, Italy
* Author to whom correspondence should be addressed.
Received: 26 August 2013 / Revised: 11 September 2013 / Accepted: 22 September 2013 / Published: 1 October 2013
(This article belongs to the Special Issue Non-Alcoholic Fatty Liver Disease Research)
View Full-Text   |   Download PDF [569 KB, uploaded 19 June 2014]   |   Browse Figure


Non-alcoholic steatohepatitis (NASH) is characterized by the presence of steatosis, inflammation and hepatocyte injury and constitutes hepatic manifestation of the metabolic syndrome. The pathogenesis of NASH is complex and implicates cross-talk between different metabolically active sites, such as liver and adipose tissue. Obesity is considered a chronic low-grade inflammatory state and the liver has been recognized as being an “immunological organ”. The complex role of the immune system in the pathogenesis of NASH is currently raising great interest, also in view of the possible therapeutic potential of immunotherapy in NASH. This review focuses on the disturbances of the cells constituting the innate and adaptive immune system in the liver and in adipose tissue.
Keywords: non-alcoholic steatohepatitis (NASH); innate immunity; adaptive immunity; adipokines non-alcoholic steatohepatitis (NASH); innate immunity; adaptive immunity; adipokines
This is an open access article distributed under the Creative Commons Attribution License (CC BY) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Share & Cite This Article

Further Mendeley | CiteULike
Export to BibTeX |
EndNote |
MDPI and ACS Style

Vonghia, L.; Michielsen, P.; Francque, S. Immunological Mechanisms in the Pathophysiology of Non-Alcoholic Steatohepatitis. Int. J. Mol. Sci. 2013, 14, 19867-19890.

View more citation formats

Related Articles

Article Metrics

For more information on the journal, click here


[Return to top]
Int. J. Mol. Sci. EISSN 1422-0067 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert