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Int. J. Mol. Sci. 2013, 14(11), 21598-21612; doi:10.3390/ijms141121598

The Effect of Different Intensities of Treadmill Exercise on Cognitive Function Deficit Following a Severe Controlled Cortical Impact in Rats

1
Department of Rehabilitation, Huashan Hospital, Fudan University, Shanghai 200040, China
2
Rehabilitation Medicine Center, Nanjing Military Region Sanatorium of Hangzhou, Hangzhou 310007, Zhejiang, China
3
Department of Rehabilitation, Shanghai Yangpu District Geriatric Hospital, Shanghai 200090, China
These authors contributed equally to this work.
*
Author to whom correspondence should be addressed.
Received: 30 August 2013 / Revised: 12 October 2013 / Accepted: 17 October 2013 / Published: 31 October 2013
(This article belongs to the Section Molecular Recognition)
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Abstract

Exercise has been proposed for the treatment of traumatic brain injury (TBI). However, the proper intensity of exercise in the early phase following a severe TBI is largely unknown. To compare two different treadmill exercise intensities on the cognitive function following a severe TBI in its early phase, rats experienced a controlled cortical impact (CCI) and were forced to treadmill exercise for 14 days. The results revealed that the rats in the low intensity exercise group had a shorter latency to locate a platform and a significantly better improvement in spatial memory in the Morris water maze (MWM) compared to the control group (p < 0.05). The high intensity exercise group showed a longer latency and a mild improvement in spatial memory compared to the control group rats in the MWM; however, this difference was not statistically significant (p > 0.05). The brain-derived neurotrophic factor (BDNF) and p-CREB protein levels in the contralateral hippocampus were increased significantly in the low intensity exercise group. Our results suggest that 2 weeks of low intensity of treadmill exercise is beneficial for improving cognitive function and increasing hippocampal BDNF expression after a severe TBI in its early phase.
Keywords: controlled cortical impact; treadmill running; spatial memory; intensity; BDNF controlled cortical impact; treadmill running; spatial memory; intensity; BDNF
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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MDPI and ACS Style

Shen, X.; Li, A.; Zhang, Y.; Dong, X.; Shan, T.; Wu, Y.; Jia, J.; Hu, Y. The Effect of Different Intensities of Treadmill Exercise on Cognitive Function Deficit Following a Severe Controlled Cortical Impact in Rats. Int. J. Mol. Sci. 2013, 14, 21598-21612.

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