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Review

Rodent Models of Nonalcoholic Fatty Liver Disease/Nonalcoholic Steatohepatitis

by
Kento Imajo
1,
Masato Yoneda
1,
Takaomi Kessoku
1,
Yuji Ogawa
1,
Shin Maeda
1,
Yoshio Sumida
2,
Hideyuki Hyogo
3,
Yuichiro Eguchi
4,
Koichiro Wada
5 and
Atsushi Nakajima
1,*
1
Department of Gastroenterology, Yokohama City University Graduate School of Medicine, 3-9 Fuku-ura, Yokohama 236-0004, Japan
2
Department of Gastroenterology and Hepatology, Kyoto Prefectural University of Medicine, Kamigyo-ku, Kyoto 602-8566, Japan
3
Department of Medicine and Molecular Science, Graduate School of Biomedical Sciences, Hiroshima University, Hiroshima 734-8551, Japan
4
Department of Internal Medicine, Saga Medical School, Saga University, Saga 849-8501, Japan
5
Department of Pharmacology, Osaka University Graduate School of Dentistry, 1-8 Yamada-oka, Suita 565-0871, Japan
*
Author to whom correspondence should be addressed.
Int. J. Mol. Sci. 2013, 14(11), 21833-21857; https://doi.org/10.3390/ijms141121833
Submission received: 27 August 2013 / Revised: 14 October 2013 / Accepted: 21 October 2013 / Published: 4 November 2013
(This article belongs to the Special Issue Non-Alcoholic Fatty Liver Disease Research)
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Abstract

Research in nonalcoholic fatty liver disease (NAFLD), including nonalcoholic steatohepatitis (NASH), has been limited by the availability of suitable models for this disease. A number of rodent models have been described in which the relevant liver pathology develops in an appropriate metabolic context. These models are promising tools for researchers investigating one of the key issues of NASH: not so much why steatosis occurs, but what causes the transition from simple steatosis to the inflammatory, progressive fibrosing condition of steatohepatitis. The different rodent models can be classified into two large groups. The first includes models in which the disease is acquired after dietary or pharmacological manipulation, and the second, genetically modified models in which liver disease develops spontaneously. To date, no single rodent model has encompassed the full spectrum of human disease progression, but individual models can imitate particular characteristics of human disease. Therefore, it is important that researchers choose the appropriate rodent models. The purpose of the present review is to discuss the metabolic abnormalities present in the currently available rodent models of NAFLD, summarizing the strengths and weaknesses of the established models and the key findings that have furthered our understanding of the disease’s pathogenesis.
Keywords: NAFLD; NASH; animal model; rodent model NAFLD; NASH; animal model; rodent model

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MDPI and ACS Style

Imajo, K.; Yoneda, M.; Kessoku, T.; Ogawa, Y.; Maeda, S.; Sumida, Y.; Hyogo, H.; Eguchi, Y.; Wada, K.; Nakajima, A. Rodent Models of Nonalcoholic Fatty Liver Disease/Nonalcoholic Steatohepatitis. Int. J. Mol. Sci. 2013, 14, 21833-21857. https://doi.org/10.3390/ijms141121833

AMA Style

Imajo K, Yoneda M, Kessoku T, Ogawa Y, Maeda S, Sumida Y, Hyogo H, Eguchi Y, Wada K, Nakajima A. Rodent Models of Nonalcoholic Fatty Liver Disease/Nonalcoholic Steatohepatitis. International Journal of Molecular Sciences. 2013; 14(11):21833-21857. https://doi.org/10.3390/ijms141121833

Chicago/Turabian Style

Imajo, Kento, Masato Yoneda, Takaomi Kessoku, Yuji Ogawa, Shin Maeda, Yoshio Sumida, Hideyuki Hyogo, Yuichiro Eguchi, Koichiro Wada, and Atsushi Nakajima. 2013. "Rodent Models of Nonalcoholic Fatty Liver Disease/Nonalcoholic Steatohepatitis" International Journal of Molecular Sciences 14, no. 11: 21833-21857. https://doi.org/10.3390/ijms141121833

APA Style

Imajo, K., Yoneda, M., Kessoku, T., Ogawa, Y., Maeda, S., Sumida, Y., Hyogo, H., Eguchi, Y., Wada, K., & Nakajima, A. (2013). Rodent Models of Nonalcoholic Fatty Liver Disease/Nonalcoholic Steatohepatitis. International Journal of Molecular Sciences, 14(11), 21833-21857. https://doi.org/10.3390/ijms141121833

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