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Int. J. Mol. Sci. 2013, 14(11), 21899-21942; doi:10.3390/ijms141121899

Solid Lipid Nanoparticle-Based Calix[n]arenes and Calix-Resorcinarenes as Building Blocks: Synthesis, Formulation and Characterization

1
INRAP, Technopôle de Sidi Thabet, Sidi Thabet 2020, Tunisia
2
School of Life Sciences, University of Applied Sciences Northwestern Switzerland, Muttenz 4132, Switzerland
3
Université Lyon 1, ICBMS UMR-CNRS 5246, CSAp, Villeurbanne F69622, France
4
LMI CNRS, UMR 5615, Villeurbanne 69622, France
*
Author to whom correspondence should be addressed.
Received: 2 September 2013 / Revised: 7 October 2013 / Accepted: 9 October 2013 / Published: 5 November 2013
(This article belongs to the Special Issue Synthesis, Characterization and Application of Supramolecular Systems)

Abstract

Solid lipid nanoparticles (SLNs) have attracted increasing attention during recent years. This paper presents an overview about the use of calix[n]arenes and calix-resorcinarenes in the formulation of SLNs. Because of their specific inclusion capability both in the intraparticle spaces and in the host cavities as well as their capacity for functionalization, these colloidal nanostructures represent excellent tools for the encapsulation of different active pharmaceutical ingredients (APIs) in the area of drug targeting, cosmetic additives, contrast agents, etc. Various synthetic routes to the supramolecular structures will be given. These various routes lead to the formulation of the corresponding SLNs. Characterization, properties, toxicological considerations as well as numerous corresponding experimental studies and analytical methods will be also exposed and discussed.
Keywords: solid lipid nanoparticles; calix[n]arenes; calix-resorcinarenes; encapsulation; colloids; supramolecular; nanocarriers solid lipid nanoparticles; calix[n]arenes; calix-resorcinarenes; encapsulation; colloids; supramolecular; nanocarriers
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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MDPI and ACS Style

Montasser, I.; Shahgaldian, P.; Perret, F.; Coleman, A.W. Solid Lipid Nanoparticle-Based Calix[n]arenes and Calix-Resorcinarenes as Building Blocks: Synthesis, Formulation and Characterization. Int. J. Mol. Sci. 2013, 14, 21899-21942.

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