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Int. J. Mol. Sci. 2013, 14(11), 22708-22720; doi:10.3390/ijms141122708

Hsa-Let-7g miRNA Targets Caspase-3 and Inhibits the Apoptosis Induced by ox-LDL in Endothelial Cells

* ,
Emergency Department, First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou 310003, China
* Author to whom correspondence should be addressed.
Received: 14 October 2013 / Revised: 29 October 2013 / Accepted: 1 November 2013 / Published: 18 November 2013
(This article belongs to the Section Biochemistry, Molecular Biology and Biophysics)
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It has been well confirmed ox-LDL plays key roles in the development of atherosclerosis via binding to LOX-1 and inducing apoptosis in vascular endothelial cells. Recent studies have shown ox-LDL can suppress microRNA has-let-7g, which in turn inhibits the ox-LDL induced apoptosis. However, details need to be uncovered. To determine the anti-atherosclerosis effect of microRNA has-let-7g, and to evaluate the possibility of CASP3 as an anti-atherosclerotic drug target by has-let-7g, the present study determined the role of hsa-let-7g miRNA in ox-LDL induced apoptosis in the vascular endothelial cells. We found that miRNA has-let-7g was suppressed during the ox-LDL-induced apoptosis in EAhy926 endothelial cells. In addition, overexpression of has-let-7g negatively regulated apoptosis in the endothelial cells by targeting caspase-3 expression. Therefore, miRNA let-7g may play important role in endothelial apoptosis and atherosclerosis.
Keywords: hsa-let-7g; caspase-3; apoptosis; ox-LDL; endothelial cells hsa-let-7g; caspase-3; apoptosis; ox-LDL; endothelial cells
This is an open access article distributed under the Creative Commons Attribution License (CC BY) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Zhang, Y.; Chen, N.; Zhang, J.; Tong, Y. Hsa-Let-7g miRNA Targets Caspase-3 and Inhibits the Apoptosis Induced by ox-LDL in Endothelial Cells. Int. J. Mol. Sci. 2013, 14, 22708-22720.

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