Next Article in Journal
Melatonin-Based Therapeutics for Neuroprotection in Stroke
Next Article in Special Issue
The Influence of Polyunsaturated Fatty Acids on the Phospholipase D Isoforms Trafficking and Activity in Mast Cells
Previous Article in Journal
Identification of Plasma Metabolomic Profiling for Diagnosis of Esophageal Squamous-Cell Carcinoma Using an UPLC/TOF/MS Platform
Previous Article in Special Issue
Roles of Rho GTPases in Intracellular Transport and Cellular Transformation
Article Menu

Export Article

Open AccessReview
Int. J. Mol. Sci. 2013, 14(5), 8912-8923; doi:10.3390/ijms14058912

Structural Basis of Membrane Trafficking by Rab Family Small G Protein

School of Biotechnology and Graduate School of Biochemistry, Yeungnam University, Gyeongsan 712-749, Korea
Received: 1 March 2013 / Revised: 1 April 2013 / Accepted: 10 April 2013 / Published: 25 April 2013
(This article belongs to the Special Issue Regulation of Membrane Trafficking and Its Potential Implications)
View Full-Text   |   Download PDF [712 KB, uploaded 19 June 2014]   |  


The Ras-superfamily of small G proteins is a family of GTP hydrolases that is regulated by GTP/GDP binding states. One member of the Ras-superfamily, Rab, is involved in the regulation of vesicle trafficking, which is critical to endocytosis, biosynthesis, secretion, cell differentiation and cell growth. The active form of the Rab proteins, which contains GTP, can recruit specific binding partners, such as sorting adaptors, tethering factors, kinases, phosphatases and motor proteins, thereby influencing vesicle formation, transport, and tethering. Many Rab proteins share the same interacting partners and perform unique roles in specific locations. Because functional loss of the Rab pathways has been implicated in a variety of diseases, the Rab GTPase family has been extensively investigated. In this review, we summarize Rab GTPase- mediated membrane trafficking while focusing on the structures of Rab protein and Rab-effector complexes. This review provides detailed information that helps explain how the Rab GTPase family is involved in membrane trafficking. View Full-Text
Keywords: membrane trafficking; ras-superfamily; small G protein; rab GTPase; protein structure membrane trafficking; ras-superfamily; small G protein; rab GTPase; protein structure

This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

Scifeed alert for new publications

Never miss any articles matching your research from any publisher
  • Get alerts for new papers matching your research
  • Find out the new papers from selected authors
  • Updated daily for 49'000+ journals and 6000+ publishers
  • Define your Scifeed now

SciFeed Share & Cite This Article

MDPI and ACS Style

Park, H.H. Structural Basis of Membrane Trafficking by Rab Family Small G Protein. Int. J. Mol. Sci. 2013, 14, 8912-8923.

Show more citation formats Show less citations formats

Related Articles

Article Metrics

Article Access Statistics



[Return to top]
Int. J. Mol. Sci. EISSN 1422-0067 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top