Dose-Dependent Protective Effect of Bisperoxovanadium against Acute Cerebral Ischemia in a Rat Model of Ischemia/Reperfusion Injury
Abstract
:1. Introduction
2. Results and Discussion
2.1. Effect of Bisperoxovanadium (bpV) on Infarct Volume
2.2. Effects of bpV on Neurological Deficits
2.3. bpV Decreased Neuron Apoptosis Induced by Cerebral Ischemic/Reperfusion Injury
2.4. Effect of bpV on Phosphorylation of Akt (Ser473)
2.5. Discussion
3. Experimental Section
3.1. Ischemic Stroke Model
3.2. Bisperoxovanadium (bpV[HOpic]) Treatment
3.3. Infarct Volume Assessment
3.4. Neurological Deficit Evaluation
3.5. Terminal Deoxynucleotidyl Transferase dUTP Nick End Labeling (TUNEL)
3.6. Western Blot Analysis
3.7. Immunohistochemistry
3.8. Statistical Analysis
4. Conclusions
Acknowledgments
Conflict of Interest
References
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Guo, J.-Y.; Ding, J.; Yuan, F.; Chen, H.; Chen, S.-W.; Tian, H.-L. Dose-Dependent Protective Effect of Bisperoxovanadium against Acute Cerebral Ischemia in a Rat Model of Ischemia/Reperfusion Injury. Int. J. Mol. Sci. 2013, 14, 12013-12022. https://doi.org/10.3390/ijms140612013
Guo J-Y, Ding J, Yuan F, Chen H, Chen S-W, Tian H-L. Dose-Dependent Protective Effect of Bisperoxovanadium against Acute Cerebral Ischemia in a Rat Model of Ischemia/Reperfusion Injury. International Journal of Molecular Sciences. 2013; 14(6):12013-12022. https://doi.org/10.3390/ijms140612013
Chicago/Turabian StyleGuo, Jian-Yi, Jun Ding, Fang Yuan, Hao Chen, Shi-Wen Chen, and Heng-Li Tian. 2013. "Dose-Dependent Protective Effect of Bisperoxovanadium against Acute Cerebral Ischemia in a Rat Model of Ischemia/Reperfusion Injury" International Journal of Molecular Sciences 14, no. 6: 12013-12022. https://doi.org/10.3390/ijms140612013
APA StyleGuo, J. -Y., Ding, J., Yuan, F., Chen, H., Chen, S. -W., & Tian, H. -L. (2013). Dose-Dependent Protective Effect of Bisperoxovanadium against Acute Cerebral Ischemia in a Rat Model of Ischemia/Reperfusion Injury. International Journal of Molecular Sciences, 14(6), 12013-12022. https://doi.org/10.3390/ijms140612013