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Int. J. Mol. Sci. 2013, 14(6), 12581-12592; doi:10.3390/ijms140612581

Anti-Inflammatory Components from the Root of Solanum erianthum

1
Department of Chinese Pharmaceutical Sciences and Chinese Medicine Resources, College of Pharmacy, China Medical University, Taichung 404, Taiwan
2
School of Pharmacy, College of Pharmacy, China Medical University, Taichung 404, Taiwan
3
Department of Cosmeceutics, China Medical University, Taichung 404, Taiwan
4
Taiwan Seed Improvement and Propagation Station, Council of Agriculture, Taichung 426, Taiwan
5
Tsuzuki Institute for Traditional Medicine, China Medical University, Taichung 404, Taiwan
6
Graduate Institute of Clinical Medical Science, China Medical University, Taichung 404, Taiwan
7
Department of Health and Nutrition Biotechnology, Asia University, Taichung 413, Taiwan
*
Authors to whom correspondence should be addressed.
Received: 10 May 2013 / Revised: 7 June 2013 / Accepted: 13 June 2013 / Published: 14 June 2013
(This article belongs to the Section Biochemistry, Molecular Biology and Biophysics)
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Abstract

Two new norsesquiterpenoids, solanerianones A and B (12), together with nine known compounds, including four sesquiterpenoids, (−)-solavetivone (3), (+)-anhydro-β-rotunol (4), solafuranone (5), lycifuranone A (6); one alkaloid, N-trans-feruloyltyramine (7); one fatty acid, palmitic acid (8); one phenylalkanoid, acetovanillone (9), and two steroids, β-sitosterol (10) and stigmasterol (11) were isolated from the n-hexane-soluble part of the roots of Solanum erianthum. Their structures were elucidated on the basis of physical and spectroscopic data analyses. The anti-inflammatory activity of these isolates was monitored by nitric oxide (NO) production in lipopolysaccharide (LPS)-activated murine macrophage RAW264.7 cells. The cytotoxicity towards human lung squamous carcinoma (CH27), human hepatocellular carcinoma (Hep 3B), human oral squamous carcinoma (HSC-3) and human melanoma (M21) cell lines was also screened by using an MTT assay. Of the compounds tested, 3 exhibited the strongest NO inhibition with the average maximum inhibition (Emax) at 100 μM and median inhibitory concentration (IC50) values of 98.23% ± 0.08% and 65.54 ± 0.18 μM, respectively. None of compounds (19) was found to possess cytotoxic activity against human cancer cell lines at concentrations up to 30 μM. View Full-Text
Keywords: Solanum erianthum; Solanaceae; root; solanerianone; norsesquiterpenoid; sesquiterpenoid; spirovetivene; anti-inflammatory; cytotoxicity Solanum erianthum; Solanaceae; root; solanerianone; norsesquiterpenoid; sesquiterpenoid; spirovetivene; anti-inflammatory; cytotoxicity
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This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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MDPI and ACS Style

Chen, Y.-C.; Lee, H.-Z.; Chen, H.-C.; Wen, C.-L.; Kuo, Y.-H.; Wang, G.-J. Anti-Inflammatory Components from the Root of Solanum erianthum. Int. J. Mol. Sci. 2013, 14, 12581-12592.

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