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Int. J. Mol. Sci. 2013, 14(6), 12650-12660; doi:10.3390/ijms140612650

Human Chorionic Gonadotropin Beta Subunit Genes CGB1 and CGB2 are Transcriptionally Active in Ovarian Cancer

1
Department of Cell Biology, Poznan University of Medical Sciences, Rokietnicka 5D, 60-806 Poznan, Poland
2
Department of Gynecologic Oncology, Poznan University of Medical Sciences, Polna 33, 60-535 Poznan, Poland
*
Author to whom correspondence should be addressed.
Received: 1 March 2013 / Revised: 28 March 2013 / Accepted: 9 May 2013 / Published: 17 June 2013
(This article belongs to the Special Issue Genes and Pathways in the Pathogenesis of Ovarian Cancer)
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Abstract

Human chorionic gonadotropin beta subunit (CGB) is a marker of pregnancy as well as trophoblastic and nontrophoblastic tumors. CGB is encoded by a cluster of six genes, of which type II genes (CGB3/9, 5 and 8) have been shown to be upregulated in relation to type I genes (CGB6/7) in both placentas and tumors. Recent studies revealed that CGB1 and CGB2, originally considered as pseudogenes, might also be active, however, the protein products of these genes have not yet been identified. Our study demonstrates the presence of CGB1 and CGB2 transcripts in ovarian carcinomas. While CGB1 and CGB2 gene activation was not detected in normal ovaries lacking cancerous development, our study demonstrates the presence of CGB1 and CGB2 transcripts in 41% of analyzed ovarian cancer cases.
Keywords: human chorionic gonadotropin beta subunit; CGB gene expression; CGB1 CGB2; ovarian cancer human chorionic gonadotropin beta subunit; CGB gene expression; CGB1 CGB2; ovarian cancer
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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Kubiczak, M.; Walkowiak, G.P.; Nowak-Markwitz, E.; Jankowska, A. Human Chorionic Gonadotropin Beta Subunit Genes CGB1 and CGB2 are Transcriptionally Active in Ovarian Cancer. Int. J. Mol. Sci. 2013, 14, 12650-12660.

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