Next Article in Journal
Non-Covalent Synthesis of Metal Oxide Nanoparticle–Heparin Hybrid Systems: A New Approach to Bioactive Nanoparticles
Previous Article in Journal
Cloning and Functional Characterization of c-Jun NH2-Terminal Kinase from the Mediterranean Species of the Whitefly Bemisia tabaci Complex
Article Menu

Export Article

Open AccessReview
Int. J. Mol. Sci. 2013, 14(7), 13447-13462; doi:10.3390/ijms140713447

The Functions and Applications of RGD in Tumor Therapy and Tissue Engineering

College of Material Chemistry and Chemical Engineering, Hangzhou Normal University, Hangzhou 310036, China
Research Center for Biomedicine and Health, Hangzhou Normal University, Hangzhou 311121, China
College of Biological and Environmental Sciences, Hangzhou Normal University, Hangzhou 310036, China
Authors to whom correspondence should be addressed.
Received: 15 May 2013 / Revised: 17 June 2013 / Accepted: 20 June 2013 / Published: 27 June 2013
View Full-Text   |   Download PDF [971 KB, uploaded 19 June 2014]   |  


Arginine-Glycine-Aspartic (RGD), is the specific recognition site of integrins with theirs ligands, and regulates cell-cell and cell-extracellular matrix interactions. The RGD motif can be combined with integrins overexpressed on the tumor neovasculature and tumor cells with a certain affinity, becoming the new target for imaging agents, and drugs, and gene delivery for tumor treatment. Further, RGD as a biomimetic peptide can also promote cell adherence to the matrix, prevent cell apoptosis and accelerate new tissue regeneration. Functionalizing material surfaces with RGD can improve cell/biomaterial interactions, which facilitates the generation of tissue-engineered constructs. This paper reviews the main functions and advantages of RGD, describes the applications of RGD in imaging agents, drugs, gene delivery for tumor therapy, and highlights the role of RGD in promoting the development of tissue engineering (bone regeneration, cornea repair, artificial neovascularization) in recent years.
Keywords: RGD; tumor therapy; tissue engineering RGD; tumor therapy; tissue engineering
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

Scifeed alert for new publications

Never miss any articles matching your research from any publisher
  • Get alerts for new papers matching your research
  • Find out the new papers from selected authors
  • Updated daily for 49'000+ journals and 6000+ publishers
  • Define your Scifeed now

SciFeed Share & Cite This Article

MDPI and ACS Style

Wang, F.; Li, Y.; Shen, Y.; Wang, A.; Wang, S.; Xie, T. The Functions and Applications of RGD in Tumor Therapy and Tissue Engineering. Int. J. Mol. Sci. 2013, 14, 13447-13462.

Show more citation formats Show less citations formats

Related Articles

Article Metrics

Article Access Statistics



[Return to top]
Int. J. Mol. Sci. EISSN 1422-0067 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top