Next Article in Journal
Induced Production of 1-Methoxy-indol-3-ylmethyl Glucosinolate by Jasmonic Acid and Methyl Jasmonate in Sprouts and Leaves of Pak Choi (Brassica rapa ssp. chinensis)
Next Article in Special Issue
Effect of a Static Magnetic Fields and Fluoride Ions on the Antioxidant Defense System of Mice Fibroblasts
Previous Article in Journal
Plant Flavonoids—Biosynthesis, Transport and Involvement in Stress Responses
Previous Article in Special Issue
Evaluation of the Gamma-H2AX Assay for Radiation Biodosimetry in a Swine Model
Int. J. Mol. Sci. 2013, 14(7), 14974-14995; doi:10.3390/ijms140714974

Could Radiotherapy Effectiveness Be Enhanced by Electromagnetic Field Treatment?

1 Department of Radiology and Physical Medicine Av. Madrid s/n, Granada 18012, Spain 2 Biohealth Research Institute of Granada C/Doctor Azpitarte 4, fourth floor, Licinio de la Fuente Building, Granada 18012, Spain 3 Ciber of Hepatic and Digestive Diseases CIBEREHD, C/Córcega 180 ground floor, right. Barcelona 08036, Spain 4 Ciber of Epidemiology .and Public Health CIBERESP San Cecilio University Hospital, Avda Madrid s/n, Granada 18012, Spain 5 Institute of Biopathology and Regenerative Medicine (IBIMER), University of Granada. Av. Conocimiento, s/n, Armilla 18100, Granada, Spain These authors contributed equally to this work.
* Author to whom correspondence should be addressed.
Received: 5 March 2013 / Revised: 25 June 2013 / Accepted: 1 July 2013 / Published: 17 July 2013
(This article belongs to the collection Radiation Toxicity in Cells)
View Full-Text   |   Download PDF [679 KB, uploaded 19 June 2014]   |   Browse Figure


One of the main goals in radiobiology research is to enhance radiotherapy effectiveness without provoking any increase in toxicity. In this context, it has been proposed that electromagnetic fields (EMFs), known to be modulators of proliferation rate, enhancers of apoptosis and inductors of genotoxicity, might control tumor recruitment and, thus, provide therapeutic benefits. Scientific evidence shows that the effects of ionizing radiation on cellular compartments and functions are strengthened by EMF. Although little is known about the potential role of EMFs in radiotherapy (RT), the radiosensitizing effect of EMFs described in the literature could support their use to improve radiation effectiveness. Thus, we hypothesized that EMF exposure might enhance the ionizing radiation effect on tumor cells, improving the effects of RT. The aim of this paper is to review reports of the effects of EMFs in biological systems and their potential therapeutic benefits in radiotherapy.
Keywords: electromagnetic fields; cancer; ELF magnetic exposure; radiotherapy; genotoxicity electromagnetic fields; cancer; ELF magnetic exposure; radiotherapy; genotoxicity
This is an open access article distributed under the Creative Commons Attribution License (CC BY) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Share & Cite This Article

Further Mendeley | CiteULike
Export to BibTeX |
EndNote |
MDPI and ACS Style

Francisco, A.-C.; Mar, S.-A.M.; Irene, C.; Sandra, R.-A.; Josefa, L.; Elisa, R.-M.; Nicolás, O.; Isabel, N.M. Could Radiotherapy Effectiveness Be Enhanced by Electromagnetic Field Treatment? Int. J. Mol. Sci. 2013, 14, 14974-14995.

View more citation formats

Related Articles

Article Metrics

For more information on the journal, click here


[Return to top]
Int. J. Mol. Sci. EISSN 1422-0067 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert