Next Article in Journal
Total Protein Extraction for Metaproteomics Analysis of Methane Producing Biofilm: The Effects of Detergents
Next Article in Special Issue
The Calcium Phosphate Matrix of FGF-2-Apatite Composite Layers Contributes to Their Biological Effects
Previous Article in Journal
Pregnane-Type Steroids from the Formosan Soft Coral Scleronephthya flexilis
Previous Article in Special Issue
Correction: Mutsuzaki, H., et al. Improved Bonding of Partially Osteomyelitic Bone to Titanium Pins Owing to Biomimetic Coating of Apatite. Int. J. Mol. Sci. 2013, 14, 24366–24379.
Int. J. Mol. Sci. 2014, 15(6), 10150-10168; doi:10.3390/ijms150610150
Review

BMP-Functionalised Coatings to Promote Osteogenesis for Orthopaedic Implants

1
,
2
,
1
,
1,*  and 1,3,*
1 School and Hospital of Stomatology, Wenzhou Medical University, Wenzhou 325027, China 2 Department of Oral Cell Biology, Academic Centre for Dentistry Amsterdam (ACTA), Research Institute MOVE, VU University Amsterdam and University of Amsterdam, Amsterdam 1081LA, The Netherlands 3 Department of Oral Implantology and Prosthetic Dentistry, Academic Centre for Dentistry Amsterdam (ACTA), Research Institute MOVE, VU University Amsterdam and University of Amsterdam, Amsterdam 1081LA, The Netherlands
* Authors to whom correspondence should be addressed.
Received: 17 April 2014 / Revised: 13 May 2014 / Accepted: 22 May 2014 / Published: 6 June 2014
(This article belongs to the Special Issue Biologic Coatings for Orthopaedic Implant)
View Full-Text   |   Download PDF [1228 KB, uploaded 19 June 2014]   |   Browse Figures

Abstract

The loss of bone integrity can significantly compromise the aesthetics and mobility of patients and can be treated using orthopaedic implants. Over the past decades; various orthopaedic implants; such as allografts; xenografts and synthetic materials; have been developed and widely used in clinical practice. However; most of these materials lack intrinsic osteoinductivity and thus cannot induce bone formation. Consequently; osteoinductive functionalisation of orthopaedic implants is needed to promote local osteogenesis and implant osteointegration. For this purpose; bone morphogenetic protein (BMP)-functionalised coatings have proven to be a simple and effective strategy. In this review; we summarise the current knowledge and recent advances regarding BMP-functionalised coatings for orthopaedic implants.
Keywords: bone morphogenetic protein; coating; orthopaedic implant; osteogenesis bone morphogenetic protein; coating; orthopaedic implant; osteogenesis
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).
SciFeed

Share & Cite This Article

Further Mendeley | CiteULike
Export to BibTeX |
EndNote |
RIS
MDPI and ACS Style

Wang, J.; Guo, J.; Liu, J.; Wei, L.; Wu, G. BMP-Functionalised Coatings to Promote Osteogenesis for Orthopaedic Implants. Int. J. Mol. Sci. 2014, 15, 10150-10168.

View more citation formats

Related Articles

Article Metrics

For more information on the journal, click here

Comments

[Return to top]
Int. J. Mol. Sci. EISSN 1422-0067 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert