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Int. J. Mol. Sci. 2014, 15(6), 11111-11125; doi:10.3390/ijms150611111

New Dihydro-β-agarofuran Sesquiterpenes from Parnassia wightiana Wall: Isolation, Identification and Cytotoxicity against Cancer Cells

1
College of Science, Northwest A&F University, Yangling 712100, China
2
College of Life Science, Northwest A&F University, Yangling 712100, China
3
College of Food Science and Engineering, Northwest A&F University, Yangling 712100, China
These authors contributed equally to this work.
*
Authors to whom correspondence should be addressed.
Received: 10 April 2014 / Revised: 1 June 2014 / Accepted: 4 June 2014 / Published: 20 June 2014
(This article belongs to the Section Green Chemistry)
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Abstract

Five new (48) and three known (13) dihydro-β-agarofuran sesquiterpene polyesters were isolated from the whole plants of Parnassia wightiana. The structures of all compounds were elucidated through spectroscopic analysis including 2D-NMR and HR-MS. The absolute configuration of these compounds was established by X-ray diffraction analysis, comparison of NOESY spectra and biogenetic means. The cytotoxities of compounds 28 were evaluated in vitro against HL-60, SMMC-7721, A549, MCF-7 and SW480 cell lines. Compounds 57 exhibited the highest activities with IC50 values of 11.8–30.1 μM in most cases. The SAR revealed that the introduction of hydroxyl group was able to significantly improve the activities of the compounds for most of the cell lines. View Full-Text
Keywords: dihydro-β-agarofuran; sesquiterpene; Parnassia wightiana; cytotoxicity dihydro-β-agarofuran; sesquiterpene; Parnassia wightiana; cytotoxicity
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MDPI and ACS Style

Lv, C.; Zheng, Z.-L.; Miao, F.; Geng, H.-L.; Zhou, L.; Liu, L.-P. New Dihydro-β-agarofuran Sesquiterpenes from Parnassia wightiana Wall: Isolation, Identification and Cytotoxicity against Cancer Cells. Int. J. Mol. Sci. 2014, 15, 11111-11125.

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