Flavonoids and Wnt/β-Catenin Signaling: Potential Role in Colorectal Cancer Therapies
Abstract
:1. Introduction
2. WNT/β-Catenin Signaling and Colorectal Cancer
3. Small Molecules as Wnt Inhibitors: Protein–Drug Interaction
Protein | Flavonoids | Molecules | References |
---|---|---|---|
sFRP | ECGC | – | [55] |
WIF-1 | ECGC | – | [56,57,5859] |
Dsh | – | NSC668036; 3289-8625; FJ9; Pen-N3 | [17,47,48,49] |
CK1a | Pyrvinium | [39] | |
TNKS | Flavonone | XAV939; JW55; JW74; AZD2281; IWR-1; G007-LK; G244-LM | [40,41,42,43,44,60,61] |
GSK-3β | Luteolin; Apigenin; Genistein | BIO | [62] |
Destruction complex * | Kaempferol; Isorhamnetin; Baicalein | – | [63] |
β-Catenin | Isoquercitrin | CCT031374; CCT036477; CCT070535 | [53,64] |
β-Catenin/TCF | Quercetin | iCRT3; iCRT5; iCRT14; PKF118–310; PKF115–584; CGP049090; BC21; UU-T02 | [10,50,51,52,54,65] |
CBP/β-catenin | – | ICG-001 | [45] |
p300/β-catenin | – | Windorphen | [46] |
Unknown | Silibinin; Wogonin | – | [9,36] |
4. Flavonoids and Wnt/β-Catenin Modulation in Colorectal Cancer
5. Conclusions
Acknowledgments
Conflicts of Interest
References
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Amado, N.G.; Predes, D.; Moreno, M.M.; Carvalho, I.O.; Mendes, F.A.; Abreu, J.G. Flavonoids and Wnt/β-Catenin Signaling: Potential Role in Colorectal Cancer Therapies. Int. J. Mol. Sci. 2014, 15, 12094-12106. https://doi.org/10.3390/ijms150712094
Amado NG, Predes D, Moreno MM, Carvalho IO, Mendes FA, Abreu JG. Flavonoids and Wnt/β-Catenin Signaling: Potential Role in Colorectal Cancer Therapies. International Journal of Molecular Sciences. 2014; 15(7):12094-12106. https://doi.org/10.3390/ijms150712094
Chicago/Turabian StyleAmado, Nathália G., Danilo Predes, Marcela M. Moreno, Igor O. Carvalho, Fábio A. Mendes, and José G. Abreu. 2014. "Flavonoids and Wnt/β-Catenin Signaling: Potential Role in Colorectal Cancer Therapies" International Journal of Molecular Sciences 15, no. 7: 12094-12106. https://doi.org/10.3390/ijms150712094