Mesenchymal Stem Cells and Induced Pluripotent Stem Cells as Therapies for Multiple Sclerosis

Xiao, Juan; Yang, Rongbing; Biswas, Sangita; Qin, Xin; Zhang, Min; Deng, Wenbin

doi:10.3390/ijms16059283

Open AccessReview

Mesenchymal Stem Cells and Induced Pluripotent Stem Cells as Therapies for Multiple Sclerosis

by

Juan Xiao

^1,2,3,†,

Rongbing Yang

^2,†,

Sangita Biswas

^3,†,

Xin Qin

¹,

Min Zhang

¹ and

Wenbin Deng

^1,3,*

¹

Medical College, Hubei University of Arts and Science, Xiangyang 441053, China

²

Department of Biological Treatment, Handan Central Hospital, Handan 056001, China

³

Department of Biochemistry and Molecular Medicine, School of Medicine, University of California, Davis, CA 95817, USA

^*

Author to whom correspondence should be addressed.

^†

These authors contributed equally to this work.

Int. J. Mol. Sci. 2015, 16(5), 9283-9302; https://doi.org/10.3390/ijms16059283

Submission received: 10 April 2015 / Revised: 20 April 2015 / Accepted: 20 April 2015 / Published: 24 April 2015

(This article belongs to the Special Issue Pluripotent Stem Cell Technology for Disease Modeling, Drug Discovery and Regenerative Medicine)

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Abstract

Multiple sclerosis (MS) is a chronic, autoimmune, inflammatory demyelinating disorder of the central nervous system that leads to permanent neurological deficits. Current MS treatment regimens are insufficient to treat the irreversible neurological disabilities. Tremendous progress in the experimental and clinical applications of cell-based therapies has recognized stem cells as potential candidates for regenerative therapy for many neurodegenerative disorders including MS. Mesenchymal stem cells (MSC) and induced pluripotent stem cell (iPSCs) derived precursor cells can modulate the autoimmune response in the central nervous system (CNS) and promote endogenous remyelination and repair process in animal models. This review highlights studies involving the immunomodulatory and regenerative effects of mesenchymal stem cells and iPSCs derived cells in animal models, and their translation into immunomodulatory and neuroregenerative treatment strategies for MS.

Keywords: mesenchymal stem cells; induced pluripotent stem cells; neural stem cell; multiple sclerosis

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MDPI and ACS Style

Xiao, J.; Yang, R.; Biswas, S.; Qin, X.; Zhang, M.; Deng, W. Mesenchymal Stem Cells and Induced Pluripotent Stem Cells as Therapies for Multiple Sclerosis. Int. J. Mol. Sci. 2015, 16, 9283-9302. https://doi.org/10.3390/ijms16059283

AMA Style

Xiao J, Yang R, Biswas S, Qin X, Zhang M, Deng W. Mesenchymal Stem Cells and Induced Pluripotent Stem Cells as Therapies for Multiple Sclerosis. International Journal of Molecular Sciences. 2015; 16(5):9283-9302. https://doi.org/10.3390/ijms16059283

Chicago/Turabian Style

Xiao, Juan, Rongbing Yang, Sangita Biswas, Xin Qin, Min Zhang, and Wenbin Deng. 2015. "Mesenchymal Stem Cells and Induced Pluripotent Stem Cells as Therapies for Multiple Sclerosis" International Journal of Molecular Sciences 16, no. 5: 9283-9302. https://doi.org/10.3390/ijms16059283

APA Style

Xiao, J., Yang, R., Biswas, S., Qin, X., Zhang, M., & Deng, W. (2015). Mesenchymal Stem Cells and Induced Pluripotent Stem Cells as Therapies for Multiple Sclerosis. International Journal of Molecular Sciences, 16(5), 9283-9302. https://doi.org/10.3390/ijms16059283

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Mesenchymal Stem Cells and Induced Pluripotent Stem Cells as Therapies for Multiple Sclerosis

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