Modified Aloe Polysaccharide Restores Chronic Stress-Induced Immunosuppression in Mice
Abstract
:1. Introduction
2. Results
2.1. Alleviation of Chronic Electric Foot Shock (EFS) Stress-Induced Body Weight Loss and Lymphoid Organ Atrophy by Modified Aloe Polysaccharide (MAP)
2.2. Alleviative Effect of MAP on Chronic EFS Stress-Induced Disturbances in Lymphocyte Subsets
2.3. Protective Effects of MAP against Chronic EFS Stress-Induced Suppression of Lymphocyte Proliferation
2.4. Protective Effect of MAP against Chronic EFS Stress-Induced Disturbance in Lymphoid Organ Subsets of Ovalbumin (OVA)-Immunized Mice
2.5. Immune Enhancing Effect of MAP on Immunoglobulin G (IgG) Production and Generation of OVA-Specific T Cells in Chronically Stressed Mice
2.6. Immune Enhancing Effect of MAP on Generation of Cytotoxic T Lymphocyte (CTL) in Chronically Stressed Mice
3. Discussion
4. Materials and Methods
4.1. Preparation of MAP
4.2. Animals and Experimental Treatments
4.3. Lymphocyte Subset Analysis
4.4. Lymphocyte Proliferation Assay
4.5. Measurement of Immunoglobulin G (IgG) Concentration in Peripheral Blood
4.6. Proliferation Assay of OVA-Specific T Lymphocytes
4.7. In Vivo Cytotoxic T Lymphocyte (CTL) Assay
4.8. Statistical Analysis
5. Conclusions
Acknowledgments
Author Contributions
Conflicts of Interest
References
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Lee, Y.; Im, S.-A.; Kim, J.; Lee, S.; Kwon, J.; Lee, H.; Kong, H.; Song, Y.; Shin, E.; Do, S.-G.; et al. Modified Aloe Polysaccharide Restores Chronic Stress-Induced Immunosuppression in Mice. Int. J. Mol. Sci. 2016, 17, 1660. https://doi.org/10.3390/ijms17101660
Lee Y, Im S-A, Kim J, Lee S, Kwon J, Lee H, Kong H, Song Y, Shin E, Do S-G, et al. Modified Aloe Polysaccharide Restores Chronic Stress-Induced Immunosuppression in Mice. International Journal of Molecular Sciences. 2016; 17(10):1660. https://doi.org/10.3390/ijms17101660
Chicago/Turabian StyleLee, Youngjoo, Sun-A Im, Jiyeon Kim, Sungwon Lee, Junghak Kwon, Heetae Lee, Hyunseok Kong, Youngcheon Song, Eunju Shin, Seon-Gil Do, and et al. 2016. "Modified Aloe Polysaccharide Restores Chronic Stress-Induced Immunosuppression in Mice" International Journal of Molecular Sciences 17, no. 10: 1660. https://doi.org/10.3390/ijms17101660