Molecular Characteristics and Treatment of Endothelial Dysfunction in Patients with COPD: A Review Article
Abstract
:1. Introduction
2. Important Characteristics and Mechanisms of the Pulmonary Endothelium
3. Inflammatory Cells and Mediators in COPD
3.1. Neutrophils’ Migration and Netosis
3.2. Macrophages and Eosinophils
3.3. Inflammatory Mediators
4. Endothelial Dysfunction and Apoptosis
5. Dysfunction of the Endothelium and its Effects in COPD Patients: Pulmonary Hypertension
6. Smoking and Endothelial Dysfunction
7. Arterial Stiffness, Aortic Pulse wave Velocity and Pulmonary Rehabilitation
8. Conclusion and Future Perspectives
Funding
Conflicts of Interest
References
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Parameter | Before Treatment | After Treatment |
---|---|---|
Sys (Hgmm) | 133.38 ± 22.15 | 126.48 ± 20.22 |
Dias (Hgmm) | 76.95 ± 14.37 | 75.4 ±12.7 |
Pulse (bpm) | 76.95 ± 14.37 | 72.53 ± 13.65 |
AIX (%) | 3.54 ± 35.59 | 2.93 ± 30.79 |
PWV (m/s) | 11.74 ± 2.13 | 11.4 ± 2.73 |
DAI (%) | 46.32 ± 6.81 | 47.1 ± 70.2 |
FEV1 (l) | 45.43 ± 20.2 | 45.06 ± 18.2 |
FVC (l) | 75.81 ± 22.71 | 74.78 ± 17.37 |
mMRC | 1.86 ± 0.71 | 1.63 ± 0.6 * |
MIP (cmH2O) | 57.72 ± 22.69 | 63.63 ± 18.01 * |
CWE (cm) | 2.84 ± 1.26 | 4.00 ± 1.76 * |
BHT (s) | 25.77 ± 10.63 | 29.21 ± 11.60 * |
GS (kg) | 24.87 ± 11.88 | 27.03 ± 11.43 * |
6MWD (m) | 335.32 ± 110.43 | 398.32 ± 126.21 * |
CAT | 17.00 ± 8.49 | 11.89 ± 7.31 * |
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Szucs, B.; Szucs, C.; Petrekanits, M.; Varga, J.T. Molecular Characteristics and Treatment of Endothelial Dysfunction in Patients with COPD: A Review Article. Int. J. Mol. Sci. 2019, 20, 4329. https://doi.org/10.3390/ijms20184329
Szucs B, Szucs C, Petrekanits M, Varga JT. Molecular Characteristics and Treatment of Endothelial Dysfunction in Patients with COPD: A Review Article. International Journal of Molecular Sciences. 2019; 20(18):4329. https://doi.org/10.3390/ijms20184329
Chicago/Turabian StyleSzucs, Botond, Csilla Szucs, Mate Petrekanits, and Janos T. Varga. 2019. "Molecular Characteristics and Treatment of Endothelial Dysfunction in Patients with COPD: A Review Article" International Journal of Molecular Sciences 20, no. 18: 4329. https://doi.org/10.3390/ijms20184329