Somatostatin as an Active Substance in the Mammalian Enteric Nervous System
Abstract
:1. Introduction
2. Organization of the Enteric Nervous System (ENS)
3. The Presence of Somatostatin (SOM) in the Enteric Neurons in Particular Mammal Species
3.1. Guinea Pig
3.2. Domestic Pig
3.3. Human
3.4. Other Mammal Species
4. Distribution of SOM Receptors in the Enteric Nervous System
5. The Plasticity of the Enteric Nervous Structures Containing Somatostatin
6. SOM in the Extrinsic Innervation of the Gastrointestinal (GI) Tract
7. Functions of Somatostatin in the Enteric Nervous System
8. Conclusions
Author Contributions
Funding
Conflicts of Interest
References
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Part of the Gastrointestinal Tract | Localization of Somatostatin | References |
---|---|---|
Human | ||
oesophagus | intramural nerve fibres, neuronal cells located in the myenteric plexus and submucous ganglia, | [21,22] |
stomach | neuronal cells in the myenteric plexus and submucous ganglia located in the pyloric region and antrum, intraganglionic nerve fibres, nerves in the muscular and mucosal layers nerves in the muscularis mucosae | [19,21,55] |
small intestine | neuronal cells located in the myenteric plexus, plexus submucous externus and plexus submucous internus, intraganglionic nerves nerves in the muscular and mucosal layers | [18,19,54,57,58] |
large intestine | neuronal cells located in the myenteric plexus, plexus submucous externus and plexus submucous internus, intraganglionic nerve fibres in all types of enteric plexuses, nerve fibres in the muscular and mucosal layers, | [18,19,53,59] |
Domestic pig | ||
oesophagus | rare intramural nerve fibres in the muscular and mucosal layer, | [52] |
stomach | single neurons in the submucous ganglia, rare nerves in the muscular and mucosal layers, | [51] |
small intestine | - neuronal cells in the myenteric, outer submucous and inner submucous plexuses, intraganglionic nerve fibres, nerve fibres in the muscular and mucosal layers, | [20,49,50] |
large intestine | neuronal cells located in the myenteric plexus, plexus submucous externus and plexus submucous internus, intraganglionic nerve fibres in all types of enteric plexuses, nerve fibres in the muscular and mucosal layers, | [17,47,48] |
Guinea pig | ||
oesophagus | rare nerve fibres in muscularis mucosae and myenteric plexus | [19] |
stomach | neuronal cells and nerve fibres in the myenteric plexus nerve fibres in the muscular layer nerve fibres in the mucosal layer | [38,39,40,41] |
small intestine | neuronal cells in the myenteric and submucous plexus nerves in the enteric ganglia, nerve fibres in the mucosal and myenteric layers | [16,26,27,28,29,30,31,32,33,34] |
large intestine | neuronal cells located in the myenteric and submucous plexus, intraganglionic nerve fibres, nerve fibres located in the muscular and mucosal layers, | [16,27,35,36,37] |
Stimulus | Character of Changes | References |
---|---|---|
Human | ||
Hirschsprung disease | ⭤ | [54] |
Hypertrophic pyloric stenosis | ⭤ | [21] |
Colonic cancer | ⭣ | [53] |
Guinea pig | ||
Embryo-foetal development | ⭡ | [93] |
Extrinsic denervation | ⭣ | [26] |
Rat | ||
Bowel resection | ⭤ | [95] |
Experimental diabetes | ⭣ | [91,92] |
Benzalkonium chloride administration | ⭣ | [92] |
Domestic pig | ||
Experimental Bacteroides fragilis infection | ⭡⭣ | [47] |
Proliferative enteropathy in the ileum | ⭡ | [20] |
Proliferative enteropathy in the colon | ⭡⭣ | [17] |
Extrinsic denervation (colon) | ⭡⭣ | [17] |
Chemically induced colitis | ⭡⭣ | [17] |
Swine dysentery (stomach) | ⭤ | [51] |
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Gonkowski, S.; Rytel, L. Somatostatin as an Active Substance in the Mammalian Enteric Nervous System. Int. J. Mol. Sci. 2019, 20, 4461. https://doi.org/10.3390/ijms20184461
Gonkowski S, Rytel L. Somatostatin as an Active Substance in the Mammalian Enteric Nervous System. International Journal of Molecular Sciences. 2019; 20(18):4461. https://doi.org/10.3390/ijms20184461
Chicago/Turabian StyleGonkowski, Slawomir, and Liliana Rytel. 2019. "Somatostatin as an Active Substance in the Mammalian Enteric Nervous System" International Journal of Molecular Sciences 20, no. 18: 4461. https://doi.org/10.3390/ijms20184461