Role of Stem Cells in the Ovarian Tissue Cryopreservation and Transplantation for Fertility Preservation
Abstract
:1. Introduction
2. Identification and Isolation of Ovarian Stem Cell
3. Ovarian Tissue Cryopreservation and Transplantation
Reference | Animal Model | Type of Stem Cells | Main Findings |
---|---|---|---|
[63] | SCID mice | Human ASCs | ASCs boosted vascularization in grafted ovarian tissue by secreting growth factor. |
[64] | SCID mice | Human ASCs | The use of ASC in fibrin implant showed an increase in oxygenation. |
[70] | Rat | Rat ASCs | Direct injection of ASCs into cryopreserved ovaries did not improve follicular survival. |
[71] | Mice | Human MSCs from bone marrow | Human MSCs isolated from bone marrow increased the levels of VEGF, FGF2, and angiogenin, stimulated neovascularization, and increased blood perfusion of transplanted grafts. |
[74] | SCID mice | Human ASCs | Prior to human ovary tissue transplantation in SCID mice, peritoneal transplantation was loaded with ASCs. Increased oxygenation, enhanced vascularization, increased primordial follicle survival rate, and decreased apoptosis rate were shown. |
4. Other Fertility Preservation Methods Using Stem Cells
4.1. Direct Injection of Stem Cells
4.2. Bone Marrow Transplantation
4.3. IVM
5. Conclusions
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Conflicts of Interest
References
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Kim, J.M.; Kim, S.; Lee, S. Role of Stem Cells in the Ovarian Tissue Cryopreservation and Transplantation for Fertility Preservation. Int. J. Mol. Sci. 2021, 22, 12482. https://doi.org/10.3390/ijms222212482
Kim JM, Kim S, Lee S. Role of Stem Cells in the Ovarian Tissue Cryopreservation and Transplantation for Fertility Preservation. International Journal of Molecular Sciences. 2021; 22(22):12482. https://doi.org/10.3390/ijms222212482
Chicago/Turabian StyleKim, Jeong Min, Seongmin Kim, and Sanghoon Lee. 2021. "Role of Stem Cells in the Ovarian Tissue Cryopreservation and Transplantation for Fertility Preservation" International Journal of Molecular Sciences 22, no. 22: 12482. https://doi.org/10.3390/ijms222212482