The PPP1R15 Family of eIF2-alpha Phosphatase Targeting Subunits (GADD34 and CReP)
Abstract
:1. Introduction
2. The Role of eIF2α Phosphatases in Cellular Stress Responses
2.1. The Unfolded Protein Response
2.2. The Genetics of eIF2α Phosphatases
2.3. eIF2α Phosphatases in Health and Disease
2.4. Pharmacological Modulation of eIF2α Phosphorylation
3. Molecular Properties and Binding Partners of GADD34 and CReP
3.1. Biochemistry of eIF2α Phosphatases
3.2. Transcriptional and Translational Regulation of GADD34 and CReP
3.3. GADD34 and CReP Binding Partners and Posttranslational Regulation
4. Diverse Cellular Functions of GADD34 and CReP
5. Future Directions
Supplementary Materials
Author Contributions
Funding
Conflicts of Interest
References
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Hicks, D.; Giresh, K.; Wrischnik, L.A.; Weiser, D.C. The PPP1R15 Family of eIF2-alpha Phosphatase Targeting Subunits (GADD34 and CReP). Int. J. Mol. Sci. 2023, 24, 17321. https://doi.org/10.3390/ijms242417321
Hicks D, Giresh K, Wrischnik LA, Weiser DC. The PPP1R15 Family of eIF2-alpha Phosphatase Targeting Subunits (GADD34 and CReP). International Journal of Molecular Sciences. 2023; 24(24):17321. https://doi.org/10.3390/ijms242417321
Chicago/Turabian StyleHicks, Danielle, Krithika Giresh, Lisa A. Wrischnik, and Douglas C. Weiser. 2023. "The PPP1R15 Family of eIF2-alpha Phosphatase Targeting Subunits (GADD34 and CReP)" International Journal of Molecular Sciences 24, no. 24: 17321. https://doi.org/10.3390/ijms242417321