Open AccessShort Note
Received: 20 December 2011 / Accepted: 9 April 2012 / Published: 17 April 2012
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Methyl 6-methyl-1-(4-methylphenyl)-2-oxo-4-phenyl-1,2,3,4-tetrahydro-pyrimidine-5-carboxylate has been synthesized via
the modified Biginelli reaction from benzaldehyde, p
-tolylurea, and methyl acetoacetate, promoted with microwave irradiation and catalyzed by TsOH under solvent-free conditions in high yield.