Molbank

6 pages, 613 KB

Open AccessShort Note

(±)-2-Chloro-N-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-2-phenylacetamide

by Diyana Dimitrova, Stanimir Manolov, Iliyan Ivanov, Dimitar Bojilov and Paraskev Nedialkov

Molbank 2026, 2026(4), M2216; https://doi.org/10.3390/M2216 - 12 Aug 2026

Herein, we report the rapid mechanochemical synthesis of a novel hybrid amide, (±)-2-chloro-N-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-2-phenylacetamide. The target compound was obtained via direct acylation of 1,4-benzodioxan-6-amine with (±)-2-chloro-2-phenylacetyl chloride under ball-milling conditions in only 1 min. Its structure was confirmed by ¹ [...] Read more.

Herein, we report the rapid mechanochemical synthesis of a novel hybrid amide, (±)-2-chloro-N-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-2-phenylacetamide. The target compound was obtained via direct acylation of 1,4-benzodioxan-6-amine with (±)-2-chloro-2-phenylacetyl chloride under ball-milling conditions in only 1 min. Its structure was confirmed by ¹H and ¹³C NMR, IR spectroscopy, and HRMS. Full article

(This article belongs to the Section Structure Determination)

► Show Figures

Figure 1

7 pages, 796 KB

Open AccessShort Note

(1E,4E)-1,5-Bis(2,4-dichlorophenyl)penta-1,4-dien-3-one Oxime

by Juan P. Montaño, Andres F. Sánchez and Rodrigo Abonia

Molbank 2026, 2026(4), M2215; https://doi.org/10.3390/M2215 - 6 Aug 2026

Abstract

The target (1E,4E)-1,5-bis(2,4-dichlorophenyl)penta-1,4-dien-3-one oxime 4 was prepared in good yield, as a key aza-precursor for the Nazarov cyclization, through a two-step sequence in this study. Initially, the starting divinyl ketone 1a was obtained via a Claisen–Schmidt condensation reaction between [...] Read more.

The target (1E,4E)-1,5-bis(2,4-dichlorophenyl)penta-1,4-dien-3-one oxime 4 was prepared in good yield, as a key aza-precursor for the Nazarov cyclization, through a two-step sequence in this study. Initially, the starting divinyl ketone 1a was obtained via a Claisen–Schmidt condensation reaction between 2,4-dichlorobenzaldehyde 3 and acetone in the presence of aqueous 20% NaOH. Subsequently, treating 1a with hydroxylamine hydrochloride under thermal conditions resulted in the expected oxime in excellent yield, and its structure was confirmed by analytic and spectroscopic techniques. Full article

► Show Figures

Figure 1

5 pages, 326 KB

Open AccessShort Note

(Z)-3′-(3-Chloro-4-fluorophenyl)-5-fluoro-5′-((6-methoxypyridin-3-yl)methylene)spiro[indoline-3,2′-thiazolidine]-2,4′-dione

by Dominika Kuceł, Jarosław Sobstyl, Serhii Holota and Dmytro Khylyuk

Molbank 2026, 2026(4), M2212; https://doi.org/10.3390/M2212 - 4 Aug 2026

Abstract

A novel spiro[indoline-3,2′-thiazolidine]-2,4′-dione derivative incorporating 3-chloro-4-fluorophenyl and 6-methoxypyridin-3-yl fragments was synthesized and characterized. The synthetic route involved a two-step procedure, including the preparation of the spirocyclic scaffold via cyclocondensation of 5-fluoroisatin with 3-chloro-4-fluoroaniline in the presence of mercaptoacetic acid, followed by Knoevenagel condensation [...] Read more.

A novel spiro[indoline-3,2′-thiazolidine]-2,4′-dione derivative incorporating 3-chloro-4-fluorophenyl and 6-methoxypyridin-3-yl fragments was synthesized and characterized. The synthetic route involved a two-step procedure, including the preparation of the spirocyclic scaffold via cyclocondensation of 5-fluoroisatin with 3-chloro-4-fluoroaniline in the presence of mercaptoacetic acid, followed by Knoevenagel condensation with 6-methoxypyridine-3-carbaldehyde. The reactions were carried out under reflux conditions and afforded the desired product in a satisfactory yield after purification by recrystallization. The structure of the synthesized compound was confirmed by ¹H and ¹³C NMR spectroscopy, LC–MS analysis, FT-IR and elemental analysis, all of which were consistent with the proposed molecular structure. The presence of multiple pharmacologically relevant heterocyclic motifs within a single framework suggests that this compound may serve as a useful scaffold for further biological evaluation. Full article

► Show Figures

Scheme 1

11 pages, 3119 KB

Open AccessCommunication

N-Demethyl-N-nitrosolevofloxacin

by Claudio Maestri, Mattia Lopresti, Ivana Miletto, Attila Benyei, Marzia Petreti, Luisa Zangirolami, Camilla Cavallotti and Giovanni B. Giovenzana

Molbank 2026, 2026(4), M2211; https://doi.org/10.3390/M2211 - 4 Aug 2026

Abstract

Levofloxacin is an antibiotic belonging to the fluoroquinolone family. N-Demethyllevofloxacin, a metabolite and an impurity of levofloxacin, features a secondary amine that is susceptible to N-nitrosation, raising concerns about the formation of a potentially toxic nitrosamine. The corresponding N-nitrosamine was [...] Read more.

Levofloxacin is an antibiotic belonging to the fluoroquinolone family. N-Demethyllevofloxacin, a metabolite and an impurity of levofloxacin, features a secondary amine that is susceptible to N-nitrosation, raising concerns about the formation of a potentially toxic nitrosamine. The corresponding N-nitrosamine was synthesized in two steps and characterized using HRMS, NMR spectroscopy, IR spectroscopy, UV absorption and emission spectroscopies and powder X-ray diffraction. This work provides a reliable reference for the quantitation and control of nitrosamine impurities associated with levofloxacin in chemical and pharmaceutical contexts. Full article

► Show Figures

Graphical abstract

7 pages, 517 KB

Open AccessShort Note

Methyl 6-(2,3-Dimethoxybenzamido)-2,3-dihydroxybenzoate

by Guo-Li Li, Zhi-Dong Yu, Na Gao, Hong-Ying Yang, Yi-Lin He and Tong Shen

Molbank 2026, 2026(4), M2213; https://doi.org/10.3390/M2213 - 4 Aug 2026

Abstract

Gymnaconitum gymnandrum, a Tibetan medicinal herb, is distributed across high-altitude regions of China. Despite its high toxicity, it exhibits analgesic, anti-inflammatory, antitumor, and other pharmacological activities. It is used topically for skin conditions and orally for rheumatism. Its main bioactive components are [...] Read more.

Gymnaconitum gymnandrum, a Tibetan medicinal herb, is distributed across high-altitude regions of China. Despite its high toxicity, it exhibits analgesic, anti-inflammatory, antitumor, and other pharmacological activities. It is used topically for skin conditions and orally for rheumatism. Its main bioactive components are alkaloids. A new organic amine alkaloid has been isolated from the plant and structurally identified using HRMS, NMR, and X-ray diffraction. Full article

(This article belongs to the Section Natural Product Chemistry)

► Show Figures

Figure 1

4 pages, 336 KB

Open AccessShort Note

Bis([1,2,5]thiadiazolo)[3,4-f:3′,4′-h]quinoxaline-8,9-dicarbonitrile

by Anastasiya S. Yushkova, Ekaterina A. Knyazeva and Oleg A. Rakitin

Molbank 2026, 2026(4), M2214; https://doi.org/10.3390/M2214 - 4 Aug 2026

Abstract

Compounds containing electron-withdrawing dicyanopyrazine and 1,2,5-chalcogenadiazole fragments are promising for the design of magnetic and optoelectronic materials. In this paper, bis([1,2,5]thiadiazolo)[3,4-f:3′,4′-h]quinoxaline-8,9-dicarbonitrile was prepared via Körner–Hinsberg condensation of benzo[1,2-c:3,4-c′]bis([1,2,5]thiadiazole)-4,5-dione with 2,3-diaminomaleonitrile in the presence of catalytic amounts of TsOH in refluxing ethanol. The structure [...] Read more.

Compounds containing electron-withdrawing dicyanopyrazine and 1,2,5-chalcogenadiazole fragments are promising for the design of magnetic and optoelectronic materials. In this paper, bis([1,2,5]thiadiazolo)[3,4-f:3′,4′-h]quinoxaline-8,9-dicarbonitrile was prepared via Körner–Hinsberg condensation of benzo[1,2-c:3,4-c′]bis([1,2,5]thiadiazole)-4,5-dione with 2,3-diaminomaleonitrile in the presence of catalytic amounts of TsOH in refluxing ethanol. The structure of the newly synthesized compound was established via elemental analysis, mass spectrometry, ¹³C NMR, and IR spectroscopy. Full article

► Show Figures

Graphical abstract

2 pages, 147 KB

Open AccessCorrection

Correction: Pasdar et al. Eco-Friendly Synthesis of Perimidine Derivatives Using Recyclable Fe₃O₄@Nano-Cellulose/Ti(IV). Molbank 2026, 2026, M2181

by Ghaffar Pasdar, Abdolhamid Bamoniri and Bi Bi Fatemeh Mirjalili

Molbank 2026, 2026(4), M2208; https://doi.org/10.3390/M2208 - 3 Aug 2026

Abstract

In the original publication [...] Full article

(This article belongs to the Collection Heterocycle Reactions)

9 pages, 1942 KB

Open AccessCommunication

A New Bis(8-hydroxyquinolinylmethyl) Perhydrobenzimidazole Obtained from a Cyclic Aminal Derived from trans-1,2-Diaminocyclohexane and 8-Hydroxyquinoline

by Augusto Rivera, Jaime Ríos-Motta and Diego Quiroga

Molbank 2026, 2026(4), M2209; https://doi.org/10.3390/M2209 - 3 Aug 2026

Abstract

The reaction of 8-hydroxyquinoline and (2R,7R,11S,16S)-1,8,10,17-tetraazapentacyclo [8.8.1.1.^8,170.^2,70.^11,16]icosane under Mannich-type conditions afforded a new quinoline-functionalized diazabicyclic derivative in 27% yield. The structure of the product was established by FT-IR, ¹H and ¹³C NMR, HSQC, HMBC, and [...] Read more.

The reaction of 8-hydroxyquinoline and (2R,7R,11S,16S)-1,8,10,17-tetraazapentacyclo [8.8.1.1.^8,170.^2,70.^11,16]icosane under Mannich-type conditions afforded a new quinoline-functionalized diazabicyclic derivative in 27% yield. The structure of the product was established by FT-IR, ¹H and ¹³C NMR, HSQC, HMBC, and ESI-MS analyses, which confirmed the connectivity between the two quinoline units and the perhydrobenzimidazole heterocyclic fragment. The conformational strain of the perhydroimidazolidine fragment prevents the rearrangement pathway previously reported for related systems, such as cyclic aminal 1,3,6,8-tetraazatricyclo [4.4.1.1^3,8]dodecane (TATD), leading to a different reaction outcome. The results demonstrate that the conformationally constrained aminal exhibits reactivity distinct from that reported for TATD-derived systems, providing new insight into the behavior of cyclic aminals in Mannich-type reactions. Full article

(This article belongs to the Collection Heterocycle Reactions)

► Show Figures

Figure 1

7 pages, 970 KB

Open AccessShort Note

N⁴-Benzoyl-N³-benzyl-2′-deoxycytidine

by Andrea Patrizia Falanga, Maria Marzano and Stefano D’Errico

Molbank 2026, 2026(4), M2210; https://doi.org/10.3390/M2210 - 3 Aug 2026

Abstract

We have recently demonstrated that the pendant tert-butyldiphenylsilyl (TBDPS) groups in the short oligonucleotides TBDPS-5′-CG-3′-3′-GC-5′-TBDPS and TBDPS-5′-CGG-3′-3′-GGC-5′-TBDPS promoted the formation of new lipophilic and stable tetramolecular G-quadruplexes (GQs). Encouraged by these findings, we sought to investigate the effect of alternative lipophilic substituents [...] Read more.

We have recently demonstrated that the pendant tert-butyldiphenylsilyl (TBDPS) groups in the short oligonucleotides TBDPS-5′-CG-3′-3′-GC-5′-TBDPS and TBDPS-5′-CGG-3′-3′-GGC-5′-TBDPS promoted the formation of new lipophilic and stable tetramolecular G-quadruplexes (GQs). Encouraged by these findings, we sought to investigate the effect of alternative lipophilic substituents at the flanking cytidine residues on GQ formation and properties. Herein, we reported on the synthesis and spectroscopic characterization of the new N⁴-benzoyl-N³-benzyl-2′-deoxycytidine, which was obtained during our attempts to synthesize N⁴-benzoyl-5′-O-benzyl-2′-deoxycytidine. Full article

(This article belongs to the Collection Molecules from Side Reactions)

► Show Figures

Graphical abstract

6 pages, 4709 KB

Open AccessShort Note

Synthesis and X-Ray Characterization of a New 1,2-Dichloroethane Solvate of 5,10,15,20-Tetraphenylporphyrin-21,23-Diium Dichloride

by Domenica Marabello, Paola Benzi and Elena Cariati

Molbank 2026, 2026(4), M2207; https://doi.org/10.3390/M2207 - 30 Jul 2026

Abstract

1,2-Dichloroethane was found to stabilize the lattice of chloride anions associated with the protonated porphyrin of formula [C₄₄H₃₂N₄]Cl₂·4C₂H₄Cl₂. The synthesis and X-ray characterization of this compound are reported and [...] Read more.

1,2-Dichloroethane was found to stabilize the lattice of chloride anions associated with the protonated porphyrin of formula [C₄₄H₃₂N₄]Cl₂·4C₂H₄Cl₂. The synthesis and X-ray characterization of this compound are reported and compared with analogous solvates. The porphyrin macrocycle displays a distorted saddle conformation, with chloride anions positioned above and below the mean plane of the ring, further surrounded by two dichloroethane molecules that stabilize the crystal packing. The Second-Harmonic Generation response was evaluated using the Kurtz–Perry powder technique with a ND:YAG laser (1064 nm). Full article

(This article belongs to the Section Structure Determination)

► Show Figures

Figure 1

5 pages, 482 KB

Open AccessShort Note

(4aS,5R,6aS,7R,11aS,11bR)-9-(1-Benzyl-1H-benzo[d]imidazol-2-yl)-4,4,7,11b-tetramethyl-1,2,3,4,4a,5,6,6a,7,11,11a,11b-dodecahydrophenanthro[3,2-b]furan-5-yl Acetate

by Jessica A. Perez-Rangel, Alejandro Islas-Jácome, Luis Chacón-García, Armando Talavera-Alemán and Carlos J. Cortés-García

Molbank 2026, 2026(4), M2206; https://doi.org/10.3390/M2206 - 17 Jul 2026

Abstract

A new benzimidazole–6β-acetoxyvouacapane (4aS,5R,6aS,7R,11aS,11bR)-9-(1-benzyl-1H-benzo[d]imidazol-2-yl)-4,4,7,11b-tetramethyl-1,2,3,4,4a,5,6,6a,7,11,11a,11b-dodecahydrophenanthro[3,2-b]furan-5-yl acetate was synthesized through the semisynthetic functionalization of the natural product 6β-acetoxyvouacapane. The target compound was obtained via a liquid-assisted mechanochemical condensation of [...] Read more.

A new benzimidazole–6β-acetoxyvouacapane (4aS,5R,6aS,7R,11aS,11bR)-9-(1-benzyl-1H-benzo[d]imidazol-2-yl)-4,4,7,11b-tetramethyl-1,2,3,4,4a,5,6,6a,7,11,11a,11b-dodecahydrophenanthro[3,2-b]furan-5-yl acetate was synthesized through the semisynthetic functionalization of the natural product 6β-acetoxyvouacapane. The target compound was obtained via a liquid-assisted mechanochemical condensation of aldehyde 6β-acetoxyvouacapane with N-benzyl-o-phenylenediamine, followed by cyclization and oxidative aromatization under mild reaction conditions. The structure of the new compound was established by FT-IR, 1D and 2D NMR spectroscopy (COSY, HSQC, and HMBC), and high-resolution mass spectrometry (HRMS). Full article

(This article belongs to the Section Natural Product Chemistry)

► Show Figures

Graphical abstract

4 pages, 406 KB

Open AccessShort Note

1,5,9-tri(Phenylethynyl)-4,8,12-trioxaphosphangulene

by Kimiya Sukegawa, Masaki Yamamura and Tatsuya Nabeshima

Molbank 2026, 2026(4), M2205; https://doi.org/10.3390/M2205 - 16 Jul 2026

Abstract

4,8,12-Trioxaphosphangulene is a bowl-shaped phosphorus-containing π-conjugated molecule whose molecular geometry is highly sensitive to the substituent attached to the phosphorus atom. Herein, we report the synthesis of a new tungsten pentacarbonyl complex of a chiral 4,8,12-trioxaphosphangulene bearing three phenylethynyl groups. The complex was [...] Read more.

4,8,12-Trioxaphosphangulene is a bowl-shaped phosphorus-containing π-conjugated molecule whose molecular geometry is highly sensitive to the substituent attached to the phosphorus atom. Herein, we report the synthesis of a new tungsten pentacarbonyl complex of a chiral 4,8,12-trioxaphosphangulene bearing three phenylethynyl groups. The complex was prepared by coordination of the phosphine center to an in situ generated W(CO)₅ fragment and was characterized by multinuclear NMR spectroscopy and elemental analysis. The NMR spectra revealed that the phosphangulene framework retains its threefold symmetry in solution. Comparison of the NMR parameters with those of a previously reported phosphangulene–tungsten complex indicates that incorporation of the phenylethynyl substituents has little effect on either the coordination environment around the phosphorus atom or the phosphine–tungsten interaction. These findings demonstrate that the characteristic bowl-shaped phosphangulene framework is preserved upon tungsten coordination despite π-extension of the molecular framework. Full article

(This article belongs to the Section Structure Determination)

► Show Figures

Figure 1

9 pages, 1489 KB

Open AccessShort Note

10-(3,5-Di-tert-butylphenyl)-9-methylacridinium Tetrafluoroborate

by Yuki Itabashi and Kei Ohkubo

Molbank 2026, 2026(4), M2203; https://doi.org/10.3390/M2203 - 14 Jul 2026

Abstract

A 9-methylacridinium salt, 10-(3,5-di-tert-butylphenyl)-9-methylacridin-10-ium tetrafluoroborate (2), was synthesized from the corresponding acridone by treatment with methylmagnesium bromide followed by tetrafluoroboric acid. Compound 2 was obtained as a yellow solid in 95% yield and characterized by NMR spectroscopy and high-resolution [...] Read more.

A 9-methylacridinium salt, 10-(3,5-di-tert-butylphenyl)-9-methylacridin-10-ium tetrafluoroborate (2), was synthesized from the corresponding acridone by treatment with methylmagnesium bromide followed by tetrafluoroboric acid. Compound 2 was obtained as a yellow solid in 95% yield and characterized by NMR spectroscopy and high-resolution mass spectrometry. Electrochemical measurements revealed irreversible reduction behavior, with a reduction potential of −0.52 V vs. SCE determined by second-harmonic alternating-current voltammetry. Compound 2 exhibited absorption extending into the visible region and fluorescence at 492 nm with a lifetime of 4.6 ns. Unlike the previously reported 9-mesityl analogue, compound 2 was fluorescent, a difference that may reflect the absence of the high-lying donor orbital associated with the 9-mesityl group. Its singlet excited-state reduction potential was estimated to be +2.21 V vs. SCE, indicating substantial photooxidizing ability. DFT and TD-DFT calculations provided complementary insight into its frontier molecular orbital distributions and principal electronic transitions. These findings highlight the influence of the 9-substituent on the electronic and emissive properties of acridinium-based photoactive molecules. Full article

(This article belongs to the Collection Molecules from Catalytic Processes)

► Show Figures

Figure 1

6 pages, 358 KB

Open AccessCommunication

Synthesis of Azirinylammonium Salts via Alkylation of DABCO with 2-Halo-2H-azirines

by Maksim A. Valiarovskii, Alexander V. Vorob’ev, Anastasiya V. Agafonova and Mikhail S. Novikov

Molbank 2026, 2026(4), M2204; https://doi.org/10.3390/M2204 - 14 Jul 2026

Abstract

Tertiary (2H-azirin-2-yl)ammonium salts were prepared from methyl 2-halo-3-aryl-2H-azirine-2-carboxylates and 1,4-diazabicyclo[2.2.2]octane in very good to excellent yields. Both iodide and bromide salts are stable enough in crystalline form to be stored in a freezer for up to several months. The [...] Read more.

Tertiary (2H-azirin-2-yl)ammonium salts were prepared from methyl 2-halo-3-aryl-2H-azirine-2-carboxylates and 1,4-diazabicyclo[2.2.2]octane in very good to excellent yields. Both iodide and bromide salts are stable enough in crystalline form to be stored in a freezer for up to several months. The structures of the obtained salts were confirmed by NMR spectroscopy and HRMS. Full article

(This article belongs to the Section Organic Synthesis and Biosynthesis)

► Show Figures

Graphical abstract

8 pages, 2161 KB

Open AccessShort Note

(5S)-5-[(2-(5-Bromo-2-methoxyphenyl)quinazolin-4-yl Amino)methyl]-3-(3-fluoro-4-morpholinophenyl)oxazolidin-2-one

by Mingguang Zhang, Siyu Hao, Baiyang Mao and Yongxu Piao

Molbank 2026, 2026(4), M2202; https://doi.org/10.3390/M2202 - 10 Jul 2026

Abstract

4-aminoquinazoline derivatives exhibit unique physiological activities, including antitumor, anti-inflammatory, and antibacterial biological activities. Afatinib (BIBW-2992), the representative tyrosine kinase inhibitor, has been developed for the treatment of non-small cell lung cancer. Following our expanded medical chemistry research program, we report a novel 4-aminoquinazoline [...] Read more.

4-aminoquinazoline derivatives exhibit unique physiological activities, including antitumor, anti-inflammatory, and antibacterial biological activities. Afatinib (BIBW-2992), the representative tyrosine kinase inhibitor, has been developed for the treatment of non-small cell lung cancer. Following our expanded medical chemistry research program, we report a novel 4-aminoquinazoline derivative named JSLN-P (1), (5S)-5-[(2-(5-bromo-2-methoxyphenyl) quinazolin-4-ylamino)methyl]-3-(3-fluoro-4-morpholino phenyl) oxazolidin-2-one, aimed for developing new drugs with antiglioma properties. The title compound JSLN-P (1) was successfully synthesized by amination approaches following benzylamination and oxazolone cyclization, further condensation with 4-(4-bromo-2-fluorophenyl) morpholine, reduction in debenzylation and halogenated amination of quinazolin. The structure of JSLN-P (1) was confirmed by ¹H and ¹³C nuclear magnetic resonance (NMR) and high-resolution mass spectrometry (HRMS). Full article

(This article belongs to the Section Organic Synthesis and Biosynthesis)

► Show Figures

Figure 1

4 pages, 234 KB

Open AccessShort Note

(E)-4-(3-Oxo-3-(2-oxo-2,3-dihydrobenzo[d]oxazol-6-yl)prop-1-en-1-yl)benzaldehyde

by Yordanka B. Ivanova, Daniel Y. Yordanov and Ognyan I. Petrov

Molbank 2026, 2026(4), M2201; https://doi.org/10.3390/M2201 - 9 Jul 2026

Abstract

In the present study, (E)-4-(3-oxo-3-(2-oxo-2,3-dihydrobenzo[d]oxazol-6-yl)prop-1-en-1-yl)benzaldehyde (2) was synthesized via a base-catalyzed Claisen–Schmidt condensation of 6-acetylbenzo[d]oxazol-2(3H)-one (1) and terephthalaldehyde and characterized by spectroscopic methods. Full article

► Show Figures

Scheme 1

5 pages, 569 KB

Open AccessShort Note

N-(4-fluorobenzyl)-N′-(4-fluorobenzylidene)-4-methylbenzenesulfonohydrazide

by Lei Gao, Li Xu, Zheng Zhang, Jinchang Zhang, Diangang Bai, Xiangrong Wang and Yue Zhang

Molbank 2026, 2026(4), M2200; https://doi.org/10.3390/M2200 - 6 Jul 2026

Abstract

Herein, we present the synthesis of N-(4-fluorobenzyl)-N’-(4-fluorobenzylidene)-4-methylbenzenesulfonohydrazide. The compound has been thoroughly characterized through melting-point determination, ¹H and ¹³C NMR spectroscopy and mass spectrometry. The structure was unequivocally determined by X-ray analysis. The comprehensive analytical data obtained from [...] Read more.

Herein, we present the synthesis of N-(4-fluorobenzyl)-N’-(4-fluorobenzylidene)-4-methylbenzenesulfonohydrazide. The compound has been thoroughly characterized through melting-point determination, ¹H and ¹³C NMR spectroscopy and mass spectrometry. The structure was unequivocally determined by X-ray analysis. The comprehensive analytical data obtained from these techniques confirm the successful preparation and structural integrity of the newly synthesized molecule. Full article

► Show Figures

Figure 1

7 pages, 1974 KB

Open AccessShort Note

Methyl 3-(Propan-2-ylidene)-3a,9a-dihydro-3H-cyclopenta[a]azulene-9-carboxylate

by Miku Yoshida, Masafumi Yasunami, Ryuta Sekiguchi, Shunji Ito and Taku Shoji

Molbank 2026, 2026(4), M2199; https://doi.org/10.3390/M2199 - 3 Jul 2026

Abstract

Methyl 3-(propan-2-ylidene)-3a,9a-dihydro-3H-cyclopenta[a]azulene-9-carboxylate (2) was synthesized in moderate yield via an [8 + 2] cycloaddition of methyl 2-oxo-2H-cyclohepta[b]furan-3-carboxylate (1) with 6,6-dimethylfulvene. The resulting compound was characterized by ¹H and ¹³C NMR spectroscopy, high-resolution mass spectrometry, and single-crystal X-ray diffraction analysis. Full article

(This article belongs to the Section Structure Determination)

► Show Figures

Figure 1

8 pages, 2007 KB

Open AccessCommunication

Synthesis of 8-Bromo-2-(chloromethyl)-6-methoxy-5-nitroimidazo[1,2-a]pyridine and 8-Bromo-2-(chloromethyl)-6-methoxy-3,5-dinitroimidazo[1,2-a]pyridine

by Inès Jacquet, Romain Paoli-Lombardo, Caroline Castera-Ducros, Patrice Vanelle and Nicolas Primas

Molbank 2026, 2026(4), M2198; https://doi.org/10.3390/M2198 - 3 Jul 2026

Abstract

A novel synthetic approach was developed to synthesize 6-methoxy substituted imidazo[1,2-a]pyridine derivatives, with the objective of obtaining analogs of previously identified antileishmanial hit compounds. The nitration of 8-bromo-2-(chloromethyl)-6-methoxyimidazo[1,2-a]pyridine under classical nitric acid/sulfuric acid conditions resulted in selective nitration at [...] Read more.

A novel synthetic approach was developed to synthesize 6-methoxy substituted imidazo[1,2-a]pyridine derivatives, with the objective of obtaining analogs of previously identified antileishmanial hit compounds. The nitration of 8-bromo-2-(chloromethyl)-6-methoxyimidazo[1,2-a]pyridine under classical nitric acid/sulfuric acid conditions resulted in selective nitration at position 5 and the corresponding 3,5-dinitrated derivative. The structures of these compounds were established through a combination of experimental methods, including ¹H and ¹³C NMR, HRMS, HSQC, and HMBC experiments. These structural determinations were subsequently confirmed through single-crystal X-ray diffraction. These compounds represent the first examples of 5-nitrated and 3,5-dinitrated 6-methoxyimidazo[1,2-a]pyridines. Full article

► Show Figures

Figure 1

Journal Description

Molbank

Latest Articles

Journal Menu

Journal Browser

Highly Accessed Articles

Latest Books

E-Mail Alert

News

Topics

Conferences

Special Issues

Topical Collections

Further Information

Guidelines

MDPI Initiatives

Follow MDPI