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Molbank
Volume 2018
Issue 1
10.3390/M981
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Communication

A Novel Disulfide-Containing Polycationic Amphiphile: 1,28-Di[(cholest-5-en-3β-yl)disulfanyl]-4,25-dioxo-3,8,12,17,21,26-hexaazaoctacosane Tetrahydrochloride

by
Pavel A. Puchkov
1,
Elena V. Shmendel
1,
Valeria D. Andreeva
1,
Nina G. Morozova
1,
Marina A. Zenkova
2 and
Mikhail A. Maslov
1,*
1
Lomonosov Institute of Fine Chemical Technologies, Moscow Technological University, Vernadsky ave. 86, 119571 Moscow, Russia
2
Institute of Chemical Biology and Fundamental Medicine SB RAS, Lavrentiev ave. 8, 630090 Novosibirsk, Russia
*
Author to whom correspondence should be addressed.
Molbank 2018, 2018(1), M981; https://doi.org/10.3390/M981
Submission received: 22 January 2018 / Revised: 12 February 2018 / Accepted: 16 February 2018 / Published: 18 February 2018
(This article belongs to the Section Organic Synthesis and Biosynthesis)
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Abstract

The absence of highly effective delivery systems is a major challenge for gene therapy. Our work was aimed at the development of novel cationic liposomes possessing high transfection efficiency. For this purpose, a novel disulfide polycationic amphiphile 2S4 was synthesized. Cationic liposomes based on 2S4 and a helper lipid DOPE were formed by the thin film hydration method and exhibited effective plasmid DNA delivery into the HEK293 cells, with a transfection activity superior to that of the commercial agent Lipofectamine® 2000. Our results suggest that the polycationic amphiphile 2S4 is a promising candidate for in vitro nucleic acid delivery.
Keywords: redox-sensitive; disulfide linker; gemini amphiphiles; cationic liposomes; gene therapy redox-sensitive; disulfide linker; gemini amphiphiles; cationic liposomes; gene therapy

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MDPI and ACS Style

Puchkov, P.A.; Shmendel, E.V.; Andreeva, V.D.; Morozova, N.G.; Zenkova, M.A.; Maslov, M.A. A Novel Disulfide-Containing Polycationic Amphiphile: 1,28-Di[(cholest-5-en-3β-yl)disulfanyl]-4,25-dioxo-3,8,12,17,21,26-hexaazaoctacosane Tetrahydrochloride. Molbank 2018, 2018, M981. https://doi.org/10.3390/M981

AMA Style

Puchkov PA, Shmendel EV, Andreeva VD, Morozova NG, Zenkova MA, Maslov MA. A Novel Disulfide-Containing Polycationic Amphiphile: 1,28-Di[(cholest-5-en-3β-yl)disulfanyl]-4,25-dioxo-3,8,12,17,21,26-hexaazaoctacosane Tetrahydrochloride. Molbank. 2018; 2018(1):M981. https://doi.org/10.3390/M981

Chicago/Turabian Style

Puchkov, Pavel A., Elena V. Shmendel, Valeria D. Andreeva, Nina G. Morozova, Marina A. Zenkova, and Mikhail A. Maslov. 2018. "A Novel Disulfide-Containing Polycationic Amphiphile: 1,28-Di[(cholest-5-en-3β-yl)disulfanyl]-4,25-dioxo-3,8,12,17,21,26-hexaazaoctacosane Tetrahydrochloride" Molbank 2018, no. 1: M981. https://doi.org/10.3390/M981

APA Style

Puchkov, P. A., Shmendel, E. V., Andreeva, V. D., Morozova, N. G., Zenkova, M. A., & Maslov, M. A. (2018). A Novel Disulfide-Containing Polycationic Amphiphile: 1,28-Di[(cholest-5-en-3β-yl)disulfanyl]-4,25-dioxo-3,8,12,17,21,26-hexaazaoctacosane Tetrahydrochloride. Molbank, 2018(1), M981. https://doi.org/10.3390/M981

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