O-((Ferrocenyl)(3-fluorophenyl)methyl)hydroxylamine

Round 1

Reviewer 1 Report

The authors have addressed nearly all the issues previously pointed out.

The title should be changed to reflect the new aim of the manuscript. As an example the title could be:” Synthesis of O-((ferrocenyl)(3-fluorophenyl)methyl)hydroxylamine scaffold as potential Inhibitors of Kynurenine Pathway"

Author Response

Reviewer: 1

Comments: The authors have addressed nearly all the issues previously pointed out. The title should be changed to reflect the new aim of the manuscript. As an example the title could be: ”Synthesis of O-((ferrocenyl)(3-fluorophenyl)methyl) hydroxylamine scaffold as potential Inhibitors of Kynurenine Pathway"

Following the suggestion of the Reviewer, we have changed the title of the manuscript as indicated. We also checked the manuscript with the ‘’writefull’’ program to address the minor spell check issue.

This manuscript is a resubmission of an earlier submission. The following is a list of the peer review reports and author responses from that submission.

Round 1

Reviewer 1 Report

The authors wish to inhibit all three enzymes upstream of the kynurenine pathway, the main tryptophan degradation pathway in mammals which is often activated in cancer. They did so by modifying one of the aromatic rings with ferrocene.

One is left curious to know the effect of the said compound on the targeted enzymes.

The authors also mentioned a possible future goal to provide a valuable precursor for radiolabeling and PET scanning. Here too, providing an experimental example would have been a plus.

The synthesis of the compound alone is not enough for publication without a stellar activity as predicted.