(2R,4aS,6aS,12bR,14aS,14bR)-N-(2-(2-(2-(2-Azidoethoxy)ethoxy)ethoxy)ethyl)-10-hydroxy-2,4a,6a,9,12b,14a-hexamethyl-11-oxo-1,2,3,4,4a,5,6,6a,11,12b,13,14,14a,14b-tetradecahydropicene-2-carboxamide

Round 1

Reviewer 1 Report

The manuscript is based on the synthesis and characterization of an interesting derivative of the compound celastrol. The results are interesting and generally well described.

 I would like to recommend the acceptance of this manuscript after responding to the comments below:

Please check the assignments of compound 4 in the IR..

I would propose that the synthesis of compounds 3 and 4 be removed from the discussion of Section 2 “Result and Discussion” as it is described in the “Materials and Methods” section.

Author Response

Comments and Suggestions for Authors

The manuscript is based on the synthesis and characterization of an interesting derivative of the compound celastrol. The results are interesting and generally well described.

 I would like to recommend the acceptance of this manuscript after responding to the comments below:

We would like to thank the Reviewer for the positive comments that we received and for the suggestions that were very useful to improve the quality of our paper.

Please check the assignments of compound 4 in the IR.

Thanks for the comment. We corrected accordingly.

I would propose that the synthesis of compounds 3 and 4 be removed from the discussion of Section 2 “Result and Discussion” as it is described in the “Materials and Methods” section.

Thanks for the comment. We corrected accordingly.

We thank the Reviewer for this comment.