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Sensors 2012, 12(4), 5005-5027; doi:10.3390/s120405005

Visualizing Sweetness: Increasingly Diverse Applications for Fluorescent-Tagged Glucose Bioprobes and Their Recent Structural Modifications

New Drug Targets Laboratory, School of Life Sciences, Gwangju Institute of Science and Technology, Gwangju 500-712, Korea
These authors contributed equally to this work.
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Authors to whom correspondence should be addressed.
Received: 28 February 2012 / Revised: 3 April 2012 / Accepted: 9 April 2012 / Published: 18 April 2012
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Abstract

Glucose homeostasis is a fundamental aspect of life and its dysregulation is associated with important diseases, such as cancer and diabetes. Traditionally, glucose radioisotopes have been used to monitor glucose utilization in biological systems. Fluorescent-tagged glucose analogues were initially developed in the 1980s, but it is only in the past decade that their use as a glucose sensor has increased significantly. These analogues were developed for monitoring glucose uptake in blood cells, but their recent applications include tracking glucose uptake by tumor cells and imaging brain cell metabolism. This review outlines the development of fluorescent-tagged glucose analogues, describes their recent structural modifications and discusses their increasingly diverse biological applications. View Full-Text
Keywords: glucose homeostasis; fluorescent-tagged glucose; bioprobe; bioimaging glucose homeostasis; fluorescent-tagged glucose; bioprobe; bioimaging
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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MDPI and ACS Style

Kim, W.H.; Lee, J.; Jung, D.-W.; Williams, D.R. Visualizing Sweetness: Increasingly Diverse Applications for Fluorescent-Tagged Glucose Bioprobes and Their Recent Structural Modifications. Sensors 2012, 12, 5005-5027.

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