Next Article in Journal
Measurement of Urinary N-Telopeptides and Serum C-Telopeptides from Type I Collagen Using a Lateral Flow-Based Immunoassay
Next Article in Special Issue
Repeatability, Reproducibility and Standardisation of a Laser Doppler Imaging Technique for the Evaluation of Normal Mouse Hindlimb Perfusion
Previous Article in Journal
Probabilistic Evaluation of Three-Dimensional Reconstructions from X-Ray Images Spanning a Limited Angle
Previous Article in Special Issue
A Wireless Accelerometer-Based Body Posture Stability Detection System and Its Application for Meditation Practitioners
Article Menu

Export Article

Open AccessArticle
Sensors 2013, 13(1), 152-164; doi:10.3390/s130100152

Detectability of Absorption and Reduced Scattering Coefficients in Frequency-Domain Measurements Using a Realistic Head Phantom

1
Department of Radiology, Duke University Medical Center, DUMC 3808, Durham, NC 27710, USA
2
Department of Radiology, Leiden University Medical Center, Albinusdreef 2, 2333 ZA Leiden, The Netherlands
*
Author to whom correspondence should be addressed.
Received: 7 November 2012 / Revised: 17 December 2012 / Accepted: 18 December 2012 / Published: 24 December 2012
(This article belongs to the Special Issue Medical & Biological Imaging)
View Full-Text   |   Download PDF [240 KB, uploaded 21 June 2014]   |  

Abstract

Detection limits of the changes in absorption and reduced scattering coefficients were investigated using a frequency-domain near-infrared system in a realistic head phantom. The results were quantified in terms of the maximum detectable depth for different activation volumes in the range of 0.8–20 microliters. The non-linear relation between the maximum detectable depth and the magnitude of changes in the absorption coefficient conform well with the Born approximation to the diffusion equation. The minimal detectable changes in the reduced scattering coefficient measured in terms of the phase signal were found to be approximately twice as large as that of the absorption coefficient using the AC signal for the same volume and at the same depth. The phase delay, which can be used to quantify the fast neuronal optical response in the human brain, showed a linear dependence on the reciprocal of the reduced scattering coefficient, as predicted by the Rytov approximation.
Keywords: near infrared; absorption; scattering; fast signal; detectability; sensitivity; frequency domain; phantom; human head near infrared; absorption; scattering; fast signal; detectability; sensitivity; frequency domain; phantom; human head
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

Scifeed alert for new publications

Never miss any articles matching your research from any publisher
  • Get alerts for new papers matching your research
  • Find out the new papers from selected authors
  • Updated daily for 49'000+ journals and 6000+ publishers
  • Define your Scifeed now

SciFeed Share & Cite This Article

MDPI and ACS Style

Zhang, X.; Webb, A. Detectability of Absorption and Reduced Scattering Coefficients in Frequency-Domain Measurements Using a Realistic Head Phantom. Sensors 2013, 13, 152-164.

Show more citation formats Show less citations formats

Related Articles

Article Metrics

Article Access Statistics

1

Comments

[Return to top]
Sensors EISSN 1424-8220 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top