Nanomaterial-Assisted Signal Enhancement of Hybridization for DNA Biosensors: A Review
Abstract
:1. Introduction
2. DNA Hybridization and Signal-Detecting Methods
3. Hybridization Signal Enhanced by Nanomaterials
3.1. Nanosemiconductors
3.2. Quantum-dots (QDs)
3.3. Nanoparticles (NPs)
3.4. Carbon nanotubes (CNTs) and their composites
4. Signal Enhancement of DNA Biosensor Based on Non-Nanomaterials for Comparison
5. Conclusions and Perspectives
Acknowledgments
References and Notes
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Signal enhancers | Signal/method | Sensitivity enhancement | Detection limit (M) | Reference |
---|---|---|---|---|
SnO2 nanorods | fluorescence | 5-fold | 1.0 × 10−12 | 43 |
nanoscale TiO2, SnO2, and Fe3O4 films | current | 2.1, 5.4, and 4.6 × 10−8, respectively | 44 | |
walnut-like CdS NPs | current/cyclic and differential pulse voltammetry | ca. 3-fold | 6.0 × 10−14 | 46 |
streptavidin-functionalized QDs | fluorescent/colorimetric measurement | < 1.0 × 10−9 | 62 | |
single-QD | fluorescence/FRET | 100-fold | 4.8 × 10−15 | 63 |
CdSe/ZnS core-shell QDs | fluorescence/FRET | < 1.0 × 10−9 | 72 | |
CdSe-ZnS QDs and magnetic beads | fluorescence/FRET | >100-fold | 5.0 × 10−13 | 74 |
ZnCdSe alloy QDs | fluorescence/FRET | ca. 15-fold | 75 | |
AuNPs | frequency | 1.0 × 10−14 | 81 | |
AuNPs | photocurrent | ca. 2-fold | 82 | |
AuNPs | current/cyclic voltammetry | 1.0 × 10−11 | 83 | |
AgNPs | fluorescence | >10-fold | 90 | |
AgNPs | fluorescence | 28-fold | 91 | |
AgNPs | current/anodic stripping voltammetry | 0.03 ng/mL (IgG) | 92 | |
MWCNTs | current/cyclic voltammetry | 3.81 × 10−11 | 98 | |
MWCNTs/ZnO/chitosan composites | current/differential pulse voltammetry | 2.8 × 10−12 | 99 | |
Au/MWCNTs | current/differential pulse voltammetry | < 1.0 × 10−12 | 100 | |
single electron transistor (non-nanomaterials) | current | 2.5 × 10−11 | 103 | |
cationic conjugated polymers and PicoGreen (non-nanomaterials) | fluorescence | 1.0 × 10−10 | 106 | |
enzyme | current | 2-fold | 1.0 × 10−9 | 108 |
enzyme | current | 1.2 × 10−11 | 110 |
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Liu, J.; Liu, J.; Yang, L.; Chen, X.; Zhang, M.; Meng, F.; Luo, T.; Li, M. Nanomaterial-Assisted Signal Enhancement of Hybridization for DNA Biosensors: A Review. Sensors 2009, 9, 7343-7364. https://doi.org/10.3390/s90907343
Liu J, Liu J, Yang L, Chen X, Zhang M, Meng F, Luo T, Li M. Nanomaterial-Assisted Signal Enhancement of Hybridization for DNA Biosensors: A Review. Sensors. 2009; 9(9):7343-7364. https://doi.org/10.3390/s90907343
Chicago/Turabian StyleLiu, Jinhuai, Jinyun Liu, Liangbao Yang, Xing Chen, Meiyun Zhang, Fanli Meng, Tao Luo, and Minqiang Li. 2009. "Nanomaterial-Assisted Signal Enhancement of Hybridization for DNA Biosensors: A Review" Sensors 9, no. 9: 7343-7364. https://doi.org/10.3390/s90907343