Pharmaceuticals 2013, 6(2), 161-183; doi:10.3390/ph6020161
Dendrimers for siRNA Delivery
Center for Pharmaceutical Biotechnology and Nanomedicine, 360 Huntington Ave, 140 The Fenway, Northeastern University, Boston, MA 02115, USA
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Received: 7 January 2013 / Revised: 17 January 2013 / Accepted: 29 January 2013 / Published: 4 February 2013
Abstract
Since the discovery of the “starburst polymer”, later renamed as dendrimer, this class of polymers has gained considerable attention for numerous biomedical applications, due mainly to the unique characteristics of this macromolecule, including its monodispersity, uniformity, and the presence of numerous functionalizable terminal groups. In recent years, dendrimers have been studied extensively for their potential application as carriers for nucleic acid therapeutics, which utilize the cationic charge of the dendrimers for effective dendrimer-nucleic acid condensation. siRNA is considered a promising, versatile tool among various RNAi-based therapeutics, which can effectively regulate gene expression if delivered successfully inside the cells. This review reports on the advancements in the development of dendrimers as siRNA carriers.
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).
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Biswas, S.; Torchilin, V.P. Dendrimers for siRNA Delivery. Pharmaceuticals 2013, 6, 161-183.
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