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Pharmaceuticals 2013, 6(8), 915-928; doi:10.3390/ph6080915

Targeting Platelet Thrombin Receptor Signaling to Prevent Thrombosis

1
Division of Cardiovascular Medicine and the Gill Heart Institute, University of Kentucky, Lexington, KY 40536, USA
2
Lexington VA Medical Center, Lexington, KY 40536, USA
*
Author to whom correspondence should be addressed.
Received: 6 May 2013 / Revised: 18 July 2013 / Accepted: 26 July 2013 / Published: 2 August 2013
(This article belongs to the Special Issue GPCR Based Drug Discovery)
View Full-Text   |   Download PDF [249 KB, uploaded 2 August 2013]   |  

Abstract

Platelets contribute fundamentally to ischemic heart disease, and antiplatelet therapy has been critical to reducing acute thrombotic complications of atherosclerotic disease. Thrombin, by acting on protease activated receptors (PAR), is one of the most potent platelet activators. PAR-1 antagonists may therefore provide more comprehensive antithrombotic effects. We review the pathophysiology of atherothrombosis, platelet activation by thrombin, the role of platelet protease activated receptors (PAR), and the clinical data supporting their use. View Full-Text
Keywords: platelets; thrombin; thrombosis; protease-activated receptors platelets; thrombin; thrombosis; protease-activated receptors
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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MDPI and ACS Style

Wallace, E.L.; Smyth, S.S. Targeting Platelet Thrombin Receptor Signaling to Prevent Thrombosis. Pharmaceuticals 2013, 6, 915-928.

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