Mar. Drugs 2012, 10(6), 1383-1390; doi:10.3390/md10061383
Chalinulasterol, a Chlorinated Steroid Disulfate from the Caribbean Sponge Chalinula molitba. Evaluation of Its Role as PXR Receptor Modulator
Roberta Teta 1, Gerardo Della Sala 1
, Barbara Renga 2, Alfonso Mangoni 1, Stefano Fiorucci 2 and Valeria Costantino 1,*
, Barbara Renga 2, Alfonso Mangoni 1, Stefano Fiorucci 2 and Valeria Costantino 1,*
1
The NeaNat Group, Department of Chemistry of Natural Products, University of Naples Federico II, Via D. Montesano 49, 80131 Napoli, Italy
2
Department of Clinical and Experimental Medicine, University of Perugia, Via Gerardo Dottori 1, S. Andrea delle Fratte, 06132 Perugia, Italy
*
Author to whom correspondence should be addressed.
Received: 20 April 2012 / Revised: 17 May 2012 / Accepted: 1 June 2012 / Published: 14 June 2012
Abstract
Chalinulasterol (1) a new chlorinated sterol disulfate was isolated from the Caribbean sponge Chalinula molitba. Its structure was elucidated using mass spectrometry and NMR experiments. The possible role of chalinulasterol as modulator of the PXR nuclear receptor was investigated but, in spite of the close structural relationship with the PXR agonist solomonsterol A (2), it showed no activity. The structural requirements for the PXR nuclear receptor activity were discussed. View Full-TextKeywords:
sterol sulfate; chlorine-containing steroid; Chalinula molitba; structure elucidation; PXR modulator
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Teta, R.; Della Sala, G.; Renga, B.; Mangoni, A.; Fiorucci, S.; Costantino, V. Chalinulasterol, a Chlorinated Steroid Disulfate from the Caribbean Sponge Chalinula molitba. Evaluation of Its Role as PXR Receptor Modulator. Mar. Drugs 2012, 10, 1383-1390.
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