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Mar. Drugs 2013, 11(7), 2655-2666; doi:10.3390/md11072655

Antioxidant and Anti-Inflammatory Activities of Barettin

1
MabCent-SFI, University of Tromsø, Breivika N-9037 Tromsø, Norway
2
Marbio, University of Tromsø, Breivika N-9037 Tromsø, Norway
3
Department of Medical Biology, Faculty of Health Sciences, University of Tromsø, N-9037 Tromsø, Norway
4
Faculty of Biosciences, Fisheries and Economics, University of Tromsø, N-9037 Tromsø, Norway
5
Department of Chemistry, University of Tromsø, N-9037 Tromsø, Norway
*
Author to whom correspondence should be addressed.
Received: 18 June 2013 / Revised: 8 July 2013 / Accepted: 17 July 2013 / Published: 22 July 2013
(This article belongs to the Special Issue Bioactive Compounds from Marine Sponges)
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Abstract

In this paper, we present novel bioactivity for barettin isolated from the marine sponge Geodia barretti. We found that barettin showed strong antioxidant activity in biochemical assays as well as in a lipid peroxidation cell assay. A de-brominated synthetic analogue of barettin did not show the same activity in the antioxidant cell assay, indicating that bromine is important for cellular activity. Barettin was also able to inhibit the secretion of the inflammatory cytokines IL-1β and TNFα from LPS-stimulated THP-1 cells. This combination of anti-inflammatory and antioxidant activities could indicate that barettin has an atheroprotective effect and may therefore be an interesting product to prevent development of atherosclerosis. View Full-Text
Keywords: anti-inflammatory; antioxidant; barettin; natural product anti-inflammatory; antioxidant; barettin; natural product
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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MDPI and ACS Style

Lind, K.F.; Hansen, E.; Østerud, B.; Eilertsen, K.-E.; Bayer, A.; Engqvist, M.; Leszczak, K.; Jørgensen, T.Ø.; Andersen, J.H. Antioxidant and Anti-Inflammatory Activities of Barettin. Mar. Drugs 2013, 11, 2655-2666.

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