Next Article in Journal
Thiopeptide Antibiotics: Retrospective and Recent Advances
Next Article in Special Issue
Identification and Biochemical Characterization of Halisulfate 3 and Suvanine as Novel Inhibitors of Hepatitis C Virus NS3 Helicase from a Marine Sponge
Previous Article in Journal
The Marine Fungal Metabolite, AD0157, Inhibits Angiogenesis by Targeting the Akt Signaling Pathway
Previous Article in Special Issue
Eight New Peptaibols from Sponge-Associated Trichoderma atroviride
Mar. Drugs 2014, 12(1), 300-316; doi:10.3390/md12010300
Article

Chitosan-Alginate Biocomposite Containing Fucoidan for Bone Tissue Engineering

1
,
2
 and
1,*
1 Marine Bioprocess Research Center, Department of Chemistry, Pukyong National University, Busan 608-737, Korea 2 Nanotheranostics Laboratory, Centre for Cellular and Molecular Biology, Hyderabad 500-007, India
* Author to whom correspondence should be addressed.
Received: 30 October 2013 / Revised: 30 December 2013 / Accepted: 30 December 2013 / Published: 16 January 2014
(This article belongs to the Special Issue Advances and New Perspectives in Marine Biotechnology)
View Full-Text   |   Download PDF [1469 KB, uploaded 24 February 2015]   |  

Abstract

Over the last few years, significant research has been conducted in the construction of artificial bone scaffolds. In the present study, different types of polymer scaffolds, such as chitosan-alginate (Chi-Alg) and chitosan-alginate with fucoidan (Chi-Alg-fucoidan), were developed by a freeze-drying method, and each was characterized as a bone graft substitute. The porosity, water uptake and retention ability of the prepared scaffolds showed similar efficacy. The pore size of the Chi-Alg and Chi-Alg-fucoidan scaffolds were measured from scanning electron microscopy and found to be 62–490 and 56–437 µm, respectively. In vitro studies using the MG-63 cell line revealed profound cytocompatibility, increased cell proliferation and enhanced alkaline phosphatase secretion in the Chi-Alg-fucoidan scaffold compared to the Chi-Alg scaffold. Further, protein adsorption and mineralization were about two times greater in the Chi-Alg-fucoidan scaffold than the Chi-Alg scaffold. Hence, we suggest that Chi-Alg-fucoidan will be a promising biomaterial for bone tissue regeneration.
Keywords: chitosan; alginate; fucoidan; bone tissue engineering; biomaterials chitosan; alginate; fucoidan; bone tissue engineering; biomaterials
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).
SciFeed

Share & Cite This Article

Further Mendeley | CiteULike
Export to BibTeX |
EndNote |
RIS
MDPI and ACS Style

Venkatesan, J.; Bhatnagar, I.; Kim, S.-K. Chitosan-Alginate Biocomposite Containing Fucoidan for Bone Tissue Engineering. Mar. Drugs 2014, 12, 300-316.

View more citation formats

Related Articles

Article Metrics

For more information on the journal, click here

Comments

[Return to top]
Mar. Drugs EISSN 1660-3397 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert