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Mar. Drugs 2014, 12(1), 300-316; doi:10.3390/md12010300

Chitosan-Alginate Biocomposite Containing Fucoidan for Bone Tissue Engineering

1
Marine Bioprocess Research Center, Department of Chemistry, Pukyong National University, Busan 608-737, Korea
2
Nanotheranostics Laboratory, Centre for Cellular and Molecular Biology, Hyderabad 500-007, India
*
Author to whom correspondence should be addressed.
Received: 30 October 2013 / Revised: 30 December 2013 / Accepted: 30 December 2013 / Published: 16 January 2014
(This article belongs to the Special Issue Advances and New Perspectives in Marine Biotechnology)
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Abstract

Over the last few years, significant research has been conducted in the construction of artificial bone scaffolds. In the present study, different types of polymer scaffolds, such as chitosan-alginate (Chi-Alg) and chitosan-alginate with fucoidan (Chi-Alg-fucoidan), were developed by a freeze-drying method, and each was characterized as a bone graft substitute. The porosity, water uptake and retention ability of the prepared scaffolds showed similar efficacy. The pore size of the Chi-Alg and Chi-Alg-fucoidan scaffolds were measured from scanning electron microscopy and found to be 62–490 and 56–437 µm, respectively. In vitro studies using the MG-63 cell line revealed profound cytocompatibility, increased cell proliferation and enhanced alkaline phosphatase secretion in the Chi-Alg-fucoidan scaffold compared to the Chi-Alg scaffold. Further, protein adsorption and mineralization were about two times greater in the Chi-Alg-fucoidan scaffold than the Chi-Alg scaffold. Hence, we suggest that Chi-Alg-fucoidan will be a promising biomaterial for bone tissue regeneration. View Full-Text
Keywords: chitosan; alginate; fucoidan; bone tissue engineering; biomaterials chitosan; alginate; fucoidan; bone tissue engineering; biomaterials
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Venkatesan, J.; Bhatnagar, I.; Kim, S.-K. Chitosan-Alginate Biocomposite Containing Fucoidan for Bone Tissue Engineering. Mar. Drugs 2014, 12, 300-316.

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