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Mar. Drugs 2014, 12(4), 2326-2340; doi:10.3390/md12042326

A New Benzofuran Glycoside and Indole Alkaloids from a Sponge-Associated Rare Actinomycete, Amycolatopsis sp.

1
Natural Products Research Institute, College of Pharmacy, Seoul National University, Seoul 151-742, Korea
2
ChunLab, Inc., Seoul National University, Seoul, 151-742, Korea
3
Department of Agricultural Biotechnology, College of Agriculture and Life Science, Seoul National University, Seoul 151-921, Korea
*
Author to whom correspondence should be addressed.
Received: 30 January 2014 / Revised: 17 March 2014 / Accepted: 28 March 2014 / Published: 22 April 2014
(This article belongs to the Special Issue Advances and New Perspectives in Marine Biotechnology)
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Abstract

Three new secondary metabolites, amycofuran (1), amycocyclopiazonic acid (2), and amycolactam (3), were isolated from the sponge-associated rare actinomycete Amycolatopsis sp. Based on combined spectroscopic analyses, the structures of 13 were determined to be a new benzofuran glycoside and new indole alkaloids related to cyclopiazonic acids, a class that has previously only been reported in fungi. The absolute configurations of 1 and 3 were deduced by ECD calculations, whereas that of 2 was determined using the modified Mosher method. Amycolactam (3) displayed significant cytotoxicity against the gastric cancer cell line SNU638 and the colon cancer cell line HCT116.
Keywords: sponge; rare actinomycete; Amycolatopsis; benzofuran; cyclopiazonic acid sponge; rare actinomycete; Amycolatopsis; benzofuran; cyclopiazonic acid
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MDPI and ACS Style

Kwon, Y.; Kim, S.-H.; Shin, Y.; Bae, M.; Kim, B.-Y.; Lee, S.K.; Oh, K.-B.; Shin, J.; Oh, D.-C. A New Benzofuran Glycoside and Indole Alkaloids from a Sponge-Associated Rare Actinomycete, Amycolatopsis sp.. Mar. Drugs 2014, 12, 2326-2340.

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