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Mar. Drugs 2014, 12(4), 2156-2163; doi:10.3390/md12042156

Two New Cytotoxic Indole Alkaloids from a Deep-Sea Sediment Derived Metagenomic Clone

1
Key Laboratory for Chemical Biology of Fujian Province, School of Pharmaceutical Sciences, Xiamen University, South Xiang-An Road, Xiamen 361102, China
2
Key Laboratory of Marine Biogenetic Resources, Third Institute of Oceanography State Oceanic Administration, Xiamen 361005, China
These authors contribute equally to this work.
*
Authors to whom correspondence should be addressed.
Received: 7 February 2014 / Revised: 7 March 2014 / Accepted: 10 March 2014 / Published: 8 April 2014
(This article belongs to the Special Issue Advances and New Perspectives in Marine Biotechnology)
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Abstract

Two new indole alkaloids, metagenetriindole A (1) and metagenebiindole A (2), were identified from deep-sea sediment metagenomic clone derived Escherichia coli fermentation broth. The structures of new compounds were elucidated by spectroscopic methods. The two new indole alkaloids demonstrated moderately cytotoxic activity against CNE2, Bel7402 and HT1080 cancer cell lines in vitro. View Full-Text
Keywords: deep-sea sediment; metagenomic clone; indole alkaloids; metagenetriindole A; metagenebiindole A; cytotoxicity deep-sea sediment; metagenomic clone; indole alkaloids; metagenetriindole A; metagenebiindole A; cytotoxicity
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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Yan, X.; Tang, X.-X.; Chen, L.; Yi, Z.-W.; Fang, M.-J.; Wu, Z.; Qiu, Y.-K. Two New Cytotoxic Indole Alkaloids from a Deep-Sea Sediment Derived Metagenomic Clone. Mar. Drugs 2014, 12, 2156-2163.

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