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Mar. Drugs, Volume 3, Issue 4 (December 2005), Pages 113-126

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Editorial

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Open AccessEditorial Farewell Address of Marine Drugs Executive Editor-in-Chief
Mar. Drugs 2005, 3(4), 126; doi:10.3390/md304126
Received: 22 December 2005 / Published: 22 December 2005
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Research

Jump to: Editorial

Open AccessArticle Luteophanol D, New Polyhydroxyl Metabolite from Marine Dinoflagellate Amphidinium sp.
Mar. Drugs 2005, 3(4), 113-118; doi:10.3390/md304113
Received: 20 October 2005 / Accepted: 2 November 2005 / Published: 2 November 2005
Cited by 27 | PDF Full-text (50 KB) | HTML Full-text | XML Full-text
Abstract
Luteophanol D (1), a new polyhydroxyl linear carbon-chain metabolite, has been isolated from the cultured marine dinoflagellate Amphidinium sp., which was isolated from Okinawan marine acoel flatworm Pseudaphanostoma luteocoloris. The structure of 1 was elucidated by detailed analyses of 2D NMR spectra. [...] Read more.
Luteophanol D (1), a new polyhydroxyl linear carbon-chain metabolite, has been isolated from the cultured marine dinoflagellate Amphidinium sp., which was isolated from Okinawan marine acoel flatworm Pseudaphanostoma luteocoloris. The structure of 1 was elucidated by detailed analyses of 2D NMR spectra. Luteophanol D (1) possesses two tetrahydropyran rings and twenty-three hydroxyl groups on C63-linear aliphatic chain with one exo-methylene and two methyl branches. Full article
Open AccessArticle Effects of Polybrominated Diphenol Ethers from a Marine Sponge Phyllospongia dendyi on IL-8 Production in a PMAstimulated Promyelocytic Leukemia Cell Line
Mar. Drugs 2005, 3(4), 119-125; doi:10.3390/md304119
Received: 28 August 2005 / Accepted: 3 November 2005 / Published: 3 November 2005
Cited by 5 | PDF Full-text (70 KB) | HTML Full-text | XML Full-text
Abstract
The effects of five polybrominated diphenol ethers from a Marine Sponge, Phyllospongia dendyi, on the relative plating efficiencies in V79 cells and the cell proliferation and IL-8 production in PMA-stimulated HL-60 cells were examined. Three compounds, possessing two phenol units, were reported [...] Read more.
The effects of five polybrominated diphenol ethers from a Marine Sponge, Phyllospongia dendyi, on the relative plating efficiencies in V79 cells and the cell proliferation and IL-8 production in PMA-stimulated HL-60 cells were examined. Three compounds, possessing two phenol units, were reported to inhibit the assembly of microtubule proteins and showed the inhibition of colony formation of V79 cells and increase in IL-8 production. Interestingly, a monomethoxy compound exhibited the stronger activity than the three active compounds in both bioassays. This compound did not inhibit the assembly of microtubule proteins. A dimethoxy compound was not active in either bioassays. In these experimental conditions, the biological activities were not high, but in future, these compounds will be expected to be made stronger by structural modifications. Full article

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