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Materials 2013, 6(5), 1599-1607; doi:10.3390/ma6051599

From Waste to Healing Biopolymers: Biomedical Applications of Bio-Collagenic Materials Extracted from Industrial Leather Residues in Wound Healing

1
Institute of Advanced Chemistry of Catalonia, IQAC, CSIC, C/Jordi Girona 18-26, Barcelona 08034, Spain
2
Department of Organic Chemistry, University of Córdoba, Campus de Rabanales, Edif. Marie Curie, Ctra. Nnal IV-A, Km 396, Córdoba E14014, Spain
*
Author to whom correspondence should be addressed.
Received: 18 February 2013 / Revised: 7 April 2013 / Accepted: 22 April 2013 / Published: 29 April 2013
(This article belongs to the Special Issue Advances in Mesoporous Materials)
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Abstract

The biomedical properties of a porous bio-collagenic polymer extracted from leather industrial waste residues have been investigated in wound healing and tissue regeneration in induced wounds in rats. Application of the pure undiluted bio-collagen to induced wounds in rats dramatically improved its healing after 7 days in terms of collagen production and wound filling as well as in the migration and differentiation of keratinocytes. The formulation tested was found to be three times more effective than the commercial reference product Catrix® (Heal Progress (HP): 8 ± 1.55 vs. 2.33 ± 0.52, p < 0.001; Formation of Collagen (FC): 7.5 ± 1.05 vs. 2.17 ± 0.75, p < 0.001; Regeneration of Epidermis (RE): 13.33 ± 5.11 vs. 5 ± 5.48, p < 0.05).
Keywords: bio-collagen; leather waste valorisation; wound healing; tissue regeneration bio-collagen; leather waste valorisation; wound healing; tissue regeneration
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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MDPI and ACS Style

Catalina, M.; Cot, J.; Borras, M.; Lapuente, J.D.; González, J.; Balu, A.M.; Luque, R. From Waste to Healing Biopolymers: Biomedical Applications of Bio-Collagenic Materials Extracted from Industrial Leather Residues in Wound Healing. Materials 2013, 6, 1599-1607.

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