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Viruses 2013, 5(7), 1740-1757; doi:10.3390/v5071740

Role of Polycomb Proteins in Regulating HSV-1 Latency

Department of Molecular Genetics and Microbiology, University of Florida College of Medicine, Box 100266, Gainesville, FL 32610, USA
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Received: 29 May 2013 / Revised: 4 July 2013 / Accepted: 4 July 2013 / Published: 15 July 2013
(This article belongs to the Special Issue Chromatin Control of Viral Infection)
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Abstract

Herpes simplex virus (HSV) establishes a latent infection within sensory neurons of humans. Latency is characterized by the transcriptional repression of lytic genes by the condensation of lytic gene regions into heterochromatin. Recent data suggest that facultative heterochromatin predominates, and that cellular Polycomb proteins are involved in the establishment and maintenance of transcriptional repression during latency. This review summarizes these data and discusses the implication of viral and cellular factors in regulating heterochromatin composition. View Full-Text
Keywords: HSV; herpes; PRC; Polycomb; heterochromatin; latency; reactivation HSV; herpes; PRC; Polycomb; heterochromatin; latency; reactivation
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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MDPI and ACS Style

Watson, Z.; Dhummakupt, A.; Messer, H.; Phelan, D.; Bloom, D. Role of Polycomb Proteins in Regulating HSV-1 Latency. Viruses 2013, 5, 1740-1757.

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