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Pharmaceutics, Volume 1, Issue 1 (December 2009), Pages 1-19

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Editorial

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Open AccessEditorial Pharmaceutics: A New Open-Access Journal for All Those Interested in Designing Medicines
Pharmaceutics 2009, 1(1), 1-2; doi:10.3390/pharmaceutics1010001
Received: 1 October 2009 / Published: 2 October 2009
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Abstract
We know the many hurdles that face us when we look to deliver a drug, starting from the basic characteristics of the drug (its solubility, stability, absorption and biodistribution), to overcoming the physiological barriers faced in reaching the target site, and to maintaining
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We know the many hurdles that face us when we look to deliver a drug, starting from the basic characteristics of the drug (its solubility, stability, absorption and biodistribution), to overcoming the physiological barriers faced in reaching the target site, and to maintaining the concentration within the therapeutic window. In addition we must also remember the patient needs in this – is it a child that needs a liquid dosage form? Is it someone having to take multiple doses in a day? Do we need a rapid onset of action in a convenient format? Will people find it convenient to take the drug in the format we are presenting to them – or are there alternative options? [...] Full article

Research

Jump to: Editorial

Open AccessArticle Effect of Ultrasound on the Compaction of Ibuprofen/Isomalt Systems
Pharmaceutics 2009, 1(1), 3-19; doi:10.3390/pharmaceutics1010003
Received: 6 August 2009 / Revised: 3 October 2009 / Accepted: 6 October 2009 / Published: 9 October 2009
PDF Full-text (1533 KB) | HTML Full-text | XML Full-text
Abstract
Six mixtures, containing 10, 20 and 30% w/w ibuprofen and isomalt, were compacted by a traditional or ultrasound-assisted machine and analysed by means of thermal (DSC and TGA) and micro-spectrometry (Raman and FT-IR) techniques. Ultrasound discharge causes melting of ibuprofen powder, transforming into
[...] Read more.
Six mixtures, containing 10, 20 and 30% w/w ibuprofen and isomalt, were compacted by a traditional or ultrasound-assisted machine and analysed by means of thermal (DSC and TGA) and micro-spectrometry (Raman and FT-IR) techniques. Ultrasound discharge causes melting of ibuprofen powder, transforming into a paste that could not assume the shape of a tablet; when in mixture with isomalt, thermal events, occurring during ultrasound compaction, change the appearance of the particles formed by milling the tablets obtained this way and SEM photos reveal a dramatic reduction of the particle size and changes due to a possible ibuprofen re-crystallization. Raman and FT-IR spectra of small portions of the surface and of the bulk, using characteristic peaks for identification, reveal that in ultrasound-compacted tablets ibuprofen partially disappears from the top face of the tablet. Full article

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