The Western Diet–Microbiome-Host Interaction and Its Role in Metabolic Disease
Abstract
:1. Ultra-Processed Foods as Drivers of Diet-Related Disease
2. Factors that Promote Inflammation through Diet-Microbiome-Host Interactions
3. Acellular Nutrients—A Major Shift in Our Diets
4. Food Additives
5. Other Components of the Western Diet that Influence Inflammation
6. Diet-Induced Inflammation and Its Role in Metabolic Disease
7. Why Nutrition Experts Disagree on Dietary Advice
8. A Complex Problem with a Simple Solution
9. Future Directions
Acknowledgments
Author Contributions
Conflicts of Interest
References
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Food Additives | Effect on Microbiota | Effect on Host Physiology | Organism/Treatment | Reference |
---|---|---|---|---|
CMC | Bacterial overgrowth | Intestinal inflammation | Mice (IL10−/−). 2% CMC, 3 weeks | [54] |
CMC, P-80 | Microbiota encroachment, altered species composition, increased pro-inflammatory potential | Colitis, metabolic syndrome | Mice (IL10−/−, TLR5−/−). 1% CMC/P-80, 12 weeks Mice (WT). 0.1–1% CMC/P-80, 12 weeks | [29] |
CMC, P-80 | Increased pro-inflammatory potential | Human colon model. 1% CMC/P-80, duration: n/a | [33] | |
P-80 | Microbiota encroachment, altered species composition, increased pro-inflammatory potential | Intestinal inflammation, obesity, liver dysfunction | Mice (WT). 1% P-80 per kg. bw, 4 weeks | [55] |
GML | Gut microbiota dysbiosis | Metabolic syndrome, systemic low-grade inflammation | Mice (WT). 150 mg·kg−1 GML, 8 weeks | [56] |
Titanium dioxide | Decrease in absorptive microvilli, decreased nutrient uptake | Human colon cells. 2.3 × 109 (high), 2.3 × 107 (medium), 2.3 × 105 (low) particles/mL | [63] | |
Sucralose | Increased expression of bacterial pro-inflammatory mediators | Elevated pro-inflammatory gene expression in the liver | Mice (WT). 0.1 mg/mL sucralose, 6 months | [62] |
NAS | Compositional and functional alterations of microbiota associated with obesity | Glucose intolerance | Mice (WT). 0.1 mg/mL−1 saccharin, 5 weeks | [28] |
Saccharin | Increased pro-inflammatory potential | Liver inflammation | Mice (WT). 0.3 mg/mL saccharin, 6 months | [61] |
Aspartame | Compositional alterations of microbiota | Glucose intolerance | Rats (WT). 5–7 mg/kg/d, 10 weeks | [59] |
Acesulfame K | Compositional and functional alterations of microbiota associated with obesity | Weight gain (male) | Mice (CD-1). 37.5 mg/kg/d, 4 weeks | [60] |
Silver nanoparticles | Gut microbial alterations associated with obesity and inflammatory diseases | Mice (WT). 46, 460 or 4600 ppb Ag NP, 28 days | [64] |
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Zinöcker, M.K.; Lindseth, I.A. The Western Diet–Microbiome-Host Interaction and Its Role in Metabolic Disease. Nutrients 2018, 10, 365. https://doi.org/10.3390/nu10030365
Zinöcker MK, Lindseth IA. The Western Diet–Microbiome-Host Interaction and Its Role in Metabolic Disease. Nutrients. 2018; 10(3):365. https://doi.org/10.3390/nu10030365
Chicago/Turabian StyleZinöcker, Marit K., and Inge A. Lindseth. 2018. "The Western Diet–Microbiome-Host Interaction and Its Role in Metabolic Disease" Nutrients 10, no. 3: 365. https://doi.org/10.3390/nu10030365