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Nutrients 2018, 10(6), 765; https://doi.org/10.3390/nu10060765

Validation of Different Nutritional Assessment Tools in Predicting Prognosis of Patients with Soft Tissue Spindle-Cell Sarcomas

1
Department of Orthopaedic Surgery, Graduate School of Medical and Dental Sciences, Kagoshima University, Kagoshima 890-8520, Japan
2
Department of Medical Joint Materials, Graduate School of Medical and Dental Sciences, Kagoshima University, Kagoshima 890-8520, Japan
*
Author to whom correspondence should be addressed.
Received: 5 April 2018 / Revised: 26 May 2018 / Accepted: 7 June 2018 / Published: 13 June 2018
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Abstract

Predicting outcomes in patients with soft tissue sarcoma (STS) is challenging. To improve these predictions, we retrospectively analyzed common nutritional assessment systems, including Glasgow prognostic score (GPS), Geriatric Nutritional Risk Index (GNRI), neutrophil–lymphocyte ratio (NLR), platelet–lymphocyte ratio (PLR), and controlling nutritional (CONUT) score against outcomes in 103 patients with STS, of whom 15 (14.6%) died within 1 year of diagnosis. GPS, GNRI, NLR, PLR, and CONUT scores significantly differed between patients who died within one year and patients who lived longer. Binomial logistic regression analysis showed that male sex, older age at diagnosis, higher GPS, higher stage, and unresectable STS were risk factors for death within a year of diagnosis. Overall survival was evaluated by Cox proportional hazards models, which correlated higher NLR, higher PLR, larger maximum diameter of tumor, higher stage, and unresectable STS with poor prognosis. We next examined prognostic factors in the 93 patients with resectable STS, and found male sex, higher GPS, and higher stage were correlated with poor prognosis in these patients. Our findings suggest that GPS, NLR, and PLR are simple predictors of outcome in patients with STS. Nutritional therapies might improve their GPS and prognosis. View Full-Text
Keywords: soft tissue sarcomas (STS); Glasgow prognostic score (GPS); Geriatric Nutritional Risk Index (GNRI); neutrophil–lymphocyte ratio (NLR); platelet–lymphocyte ratio (PLR); controlling nutritional (CONUT) score; prognosis soft tissue sarcomas (STS); Glasgow prognostic score (GPS); Geriatric Nutritional Risk Index (GNRI); neutrophil–lymphocyte ratio (NLR); platelet–lymphocyte ratio (PLR); controlling nutritional (CONUT) score; prognosis
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).
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Sasaki, H.; Nagano, S.; Komiya, S.; Taniguchi, N.; Setoguchi, T. Validation of Different Nutritional Assessment Tools in Predicting Prognosis of Patients with Soft Tissue Spindle-Cell Sarcomas. Nutrients 2018, 10, 765.

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