Obesity Status Affects the Relationship Between Protein Intake and Insulin Sensitivity in Late Pregnancy
Abstract
:1. Introduction
2. Materials and Methods
2.1. Anthropometrics
2.2. Energy Expenditure
2.3. Insulin Sensitivity Analysis
2.4. Dietary Intake
2.5. Statistical Analysis
3. Results
3.1. The Prediction of MCR Based on Dietary Protein Using Regressions
4. Discussion
5. Conclusions
Author Contributions
Funding
Acknowledgments
Conflicts of Interest
References
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Combined n = 173 | NW n = 72 | OW n = 71 | OB n = 30 | |
---|---|---|---|---|
Age (years) | 29.7 ± 0.3 | 30.0 ± 0.4 | 29.8 ± 0.4 | 29.2 ± 0.7 |
Early Pregnancy BMI (kg/m2) | 25.8 ± 0.3 | 21.9 ± 0.2 | 26.8 ± 0.2 * | 32.2 ± 0.3 * ‡ |
GWG (kg) | 8.6 ± 0.2 | 9.2 ± 0.2 | 8.7 ± 0.3 | 7.1 ± 0.5 * ‡ |
Resting Energy Expenditure (kcal/day) | 1629 ± 16 | 1525 ± 21 | 1671 ± 24 * | 1794 ± 48 * ‡ |
Fasting Insulin (µIU/mL) | 8.87 ± 0.40 | 6.23 ± 0.42 | 10.24 ± 0.65 * | 11.82 ± 0.99 * ‡ |
Fasting Glucose (mmol/L) | 4.48 ± 0.3 | 4.35 ± 0.4 | 4.57 ± 0.04 * | 4.57 ± 0.07 * |
MCR1 (mg·kg−1·min−1) | 5.53 ± 0.21 | 6.96 ± 0.26 | 4.46 ± 0.27 * | 3.36 ± 0.37 * ‡ |
MCR2 (mg·kg−1·min−1) | 5.31 ± 0.19 | 6.15 ± 0.27 | 4.55 ± 0.29 * | 4.64 ± 0.47 * |
MCR3 (mg·kg−1·min−1) | 8.07 ± 0.12 | 8.86 ± 0.13 | 7.57 ± 0.20 * | 7.33 ± 0.30 * |
MCR4 (mg·kg−1·min−1) | 7.36 ± 0.12 | 8.10 ± 0.14 | 6.92 ± 0.18 * | 6.57 ± 0.32 * |
HOMA2-IR | 1.12 ± 0.05 | 0.78 ± 0.05 | 1.29 ± 0.08 * | 1.49 ± 0.12 * |
TP (g/day) | 74.28 ± 1.44 | 74.48 ± 2.37 | 74.35 ± 2.19 | 73.72 ± 3.21 |
TP (g·kg−1·day−1) | 0.96 ± 0.02 | 1.07 ± 0.03 | 0.93 ± 0.03 * | 0.79 ± 0.04 *‡ |
AP (g/day) | 47.99 ± 1.29 | 47.14 ± 1.99 | 48.66 ± 2.03 | 48.48 ± 3.07 |
AP (g·kg−1·day−1) | 0.62 ± 0.02 | 0.68 ± 0.03 | 0.61 ± 0.03 * | 0.52 ± 0.03 * ‡ |
PP (g/day) | 26.68 ± 0.58 | 27.85 ± 0.94 | 26.19 ± 0.91 | 25.17 ± 1.14 * |
PP (g·kg−1·day−1) | 0.35 ± 0.01 | 0.40 ± 0.01 | 0.33 ± 0.01 * | 0.27 ± 0.01 * |
n | TP | AP | PP | ||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
No Adj. | Adj. | No Adj. | Adj. | No Adj. | Adj. | ||||||||
β | p | β | p | β | p | β | p | β | p | β | p | ||
MCR1 | 145 | 3.59 | 0.006 | 2.03 | 0.19 | 13.09 | <0.001 | ||||||
MCR2 | 134 | 1.91 | 0.09 | −0.07 | 0.95 | 0.70 | 0.61 | −0.74 | 0.57 | 8.50 | 0.002 | 2.88 | 0.32 |
MCR3 | 151 | 1.52 | 0.001 | 0.82 | 0.06 | 1.11 | 0.04 | 0.60 | 0.23 | 4.61 | <0.001 | 2.51 | 0.03 |
MCR4 | 152 | 1.37 | 0.002 | 0.64 | 0.01 | 0.95 | 0.08 | 0.39 | 0.43 | 4.44 | <0.001 | 2.39 | 0.03 |
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Allman, B.R.; Diaz Fuentes, E.; Williams, D.K.; Turner, D.E.; Andres, A.; Børsheim, E. Obesity Status Affects the Relationship Between Protein Intake and Insulin Sensitivity in Late Pregnancy. Nutrients 2019, 11, 2190. https://doi.org/10.3390/nu11092190
Allman BR, Diaz Fuentes E, Williams DK, Turner DE, Andres A, Børsheim E. Obesity Status Affects the Relationship Between Protein Intake and Insulin Sensitivity in Late Pregnancy. Nutrients. 2019; 11(9):2190. https://doi.org/10.3390/nu11092190
Chicago/Turabian StyleAllman, Brittany R., Eva Diaz Fuentes, D. Keith Williams, Donald E. Turner, Aline Andres, and Elisabet Børsheim. 2019. "Obesity Status Affects the Relationship Between Protein Intake and Insulin Sensitivity in Late Pregnancy" Nutrients 11, no. 9: 2190. https://doi.org/10.3390/nu11092190