The Many Ages of Microbiome–Gut–Brain Axis
Abstract
:1. Introduction
2. Materials and Methods
2.1. Mice and Behavioral Tests
2.2. Bacterial DNA Extraction and 16s rRNA Sequencing
2.3. Illumina Data Processing and Microbiota Characterization
2.4. Data Analysis and Statistics
3. Results
3.1. Sequencing Data Results
3.2. Aging Affects Overall Gut Microbiome Composition
3.3. Detailed Microbiome Composition and Aging Distribution
3.4. Aging and Cognitive Frailty Index on Microbiome Composition
4. Discussion
Supplementary Materials
Author Contributions
Funding
Institutional Review Board Statement
Data Availability Statement
Acknowledgments
Conflicts of Interest
References
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Shannon Index | ||
---|---|---|
Combination | WSRT | FDR p-Value |
T0–T1 | 17 | 0.092 |
T1–T2 | 6 | 0.007 |
T2–T3 | 13 | 0.011 |
T3–T4 | 41 | 0.787 |
Faith’s PD Index | ||
Combination | WSRT | FDR p-Value |
T0–T1 | 36 | 0.850 |
T1–T2 | 31 | 0.569 |
T2–T3 | 24 | 0.0785 |
T3–T4 | 0 | 0.0002 |
Combination | SumsOfSqs | MeanSqs | F.Model | R2 | p-Value. Corrected |
T0–T1 | 0.191 | 0.191 | 2.200 | 0.084 | 0.029 |
T1–T2 | 0.205 | 0.205 | 2.317 | 0.088 | 0.004 |
T1–T3 | 0.746 | 0.746 | 6.188 | 0.205 | 0.001 |
T2–T3 | 0.351 | 0.351 | 2.516 | 0.088 | 0.001 |
T3–T4 | 0.301 | 0.301 | 1.555 | 0.059 | 0.109 |
Genera | Published Effects on Host Health | Changes with Cognitive Frailty Increase | Possible Role |
---|---|---|---|
Parabacteroides | Dichotomous role demonstrated also in CNS [62,63,64]. | Decrease | Dysbiotic/Adaptive |
Clostridia UCG-014 | Pro-inflammatory [65,66,67]. | Decrease | Adaptive |
Oscillibacter | Negatively related to cognitive performance [68]; related to depression [60,69], metabolic disease [70], and inflammation [71]. | Decrease | Adaptive |
Mucispirillum | Opportunistic pathogens [72]; positively related to inflammation, LPS [72,73,74], and changes in different behavioral domains [75]. | Decrease | Dysbiotic |
Coprostanoligenes | Negatively related to inflammation [76,77,78]. | Decrease | Dysbiotic |
Flavonifractor | Dichotomous role, also demonstrated in CNS [79,80,81,82]. | Decrease | Dysbiotic/Adaptive |
Blautia | Butyrate producer with probiotic potential [83]. | Decrease | Dysbiotic |
Monoglobus | Negatively related to amyloid presence in the brain [84]. | Decrease | Dysbiotic |
Lachnoclostridium | Butyrate producer [85,86]. | Decrease | Dysbiotic |
Oscillospiraceae UCG_005 | Negatively related to inflammation [81]. | Decrease | Dysbiotic |
Marvinbryantia | Negatively related to amyloid presence in the brain [84]. | Decrease | Dysbiotic |
Erysipelotrichaceae | Pro-inflammatory [87,88,89]; enriched in mouse AD model and senescence-accelerated mice model [87,89]. | Decrease | Adaptive |
Clostridium sensu stricto 1, known also as C. butyricum [90] | Dichotomous role [91,92,93,94,95]. | Decrease | Dysbiotic/Adaptive |
Halomonas | Dichotomous role [96,97]. | Decrease | Dysbiotic/Adaptive |
Ruminococcus | Pro-inflammatory [98,99,100]; dysregulated in patients with depression, physical frailty and sarcopenia, AD, and PD and MCI [80,101,102,103,104]; risk indicator of MCI [105]; negatively related to cognitive performance [103,104,105] and to marker of neuronal health [106]. | Increase | Dysbiotic |
Colidextribacter | Positively related to inflammation [65,107]; decreased in PD patients [108]. | Increase | Dysbiotic |
Anaerotruncus | Dichotomous role [109,110,111,112], also in CNS (AD, PD, and cognitive impairment) [109,113,114]. | Increase | Dysbiotic/Adaptive |
Anaeroplasma | Healthy bacterium [115] decreased in AD mice model [116] and in obese rats [117]; negatively related to inflammation [118]. | Increase | Adaptive |
Peptococcaceae | Pro-inflammatory [118,119]. | Increase | Dysbiotic |
Lactobacillus | Anti-inflammatory, butyrate producer with probiotic effect [120,121,122], its beneficial effects are demonstrated also in CNS (altered behaviors, depression, anxiety, stress, cognitive impairment, andAD models) [123,124,125,126,127,128]; reduced sarcopenic process and physical frailty in mice [129]. | Increase | Adaptive |
Ruminococcaceae incertae sedis | Anti-inflammatory, butyrate producer [130]. | Increase | Adaptive |
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Ratto, D.; Roda, E.; Romeo, M.; Venuti, M.T.; Desiderio, A.; Lupo, G.; Capelli, E.; Sandionigi, A.; Rossi, P. The Many Ages of Microbiome–Gut–Brain Axis. Nutrients 2022, 14, 2937. https://doi.org/10.3390/nu14142937
Ratto D, Roda E, Romeo M, Venuti MT, Desiderio A, Lupo G, Capelli E, Sandionigi A, Rossi P. The Many Ages of Microbiome–Gut–Brain Axis. Nutrients. 2022; 14(14):2937. https://doi.org/10.3390/nu14142937
Chicago/Turabian StyleRatto, Daniela, Elisa Roda, Marcello Romeo, Maria Teresa Venuti, Anthea Desiderio, Giuseppe Lupo, Enrica Capelli, Anna Sandionigi, and Paola Rossi. 2022. "The Many Ages of Microbiome–Gut–Brain Axis" Nutrients 14, no. 14: 2937. https://doi.org/10.3390/nu14142937