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Nutrients 2013, 5(7), 2268-2275; doi:10.3390/nu5072268
Article

Vitamin D Status Is Associated with Disease Activity among Rheumatology Outpatients

1
,
1
 and
2,*
1 Department of Internal Medicine, College of Medicine, University of Saskatchewan, Saskatoon, SK S7J 5B6, Canada 2 Division of Nutrition and Dietetics, College of Pharmacy and Nutrition, School of Public Health, University of Saskatchewan, Saskatoon SK S7N 5C9, Canada
* Author to whom correspondence should be addressed.
Received: 27 March 2013 / Revised: 6 June 2013 / Accepted: 6 June 2013 / Published: 26 June 2013
(This article belongs to the Special Issue Vitamin D and Human Health)
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Abstract

The co-existence of high prevalence of vitamin D inadequacy among Canadians and high prevalence of systematic autoimmune rheumatic diseases (SARDs) raise the question on relationship between the two situations. Objective: To determine vitamin D status in known cases of common SARDs and compare to those with non-autoimmune diseases; further, to evaluate the impact of vitamin D on disease activity in rheumatoid arthritis (RA) cases. Methods: In a retrospective case-control study design, we evaluated 116 patients in a community clinic classified in two groups, Control group: patients with non-rheumatic disease (n = 56), and Case group: those with rheumatic diseases (n = 60). We compared plasma vitamin D status (25(OH)D), indicators of disease activity and other potential confounders. Further, we determined factors associated with disease activity in RA cases. Results: The plasma 25(OH)D was significantly lower in Case group (64.8 ± 29.8) compared to Control group (86.8 ± 37.7). High number of SARDs outpatients 56%) had considerably low plasma 25(OH)D concentration. RA cases with low plasma 25(OH)D had over five times higher risk of disease activity (OR = 5.15 95% CI 1.16, 22.9; p = 0.031). Conclusion: Inadequate vitamin D status in SARDs cases, along with considerably strong association with disease activity in RA cases, indicate the need for proper evaluation of vitamin D status in this clinical population. Moreover, appropriate training should be given to the patients to ensure the intake of the recommended amount of vitamin D per day through diet or supplement.
Keywords: rheumatic disease; rheumatoid arthritis; vitamin D; inflammation; disease activity rheumatic disease; rheumatoid arthritis; vitamin D; inflammation; disease activity
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).
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Sabbagh, Z.; Markland, J.; Vatanparast, H. Vitamin D Status Is Associated with Disease Activity among Rheumatology Outpatients. Nutrients 2013, 5, 2268-2275.

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