Altered Preconception Fatty Acid Intake Is Associated with Improved Pregnancy Rates in Overweight and Obese Women Undertaking in Vitro Fertilisation
Abstract
:1. Introduction
2. Experimental Section
2.1. Participants
2.2. Intervention
2.3. Outcomes
2.4. Statistical Analysis
3. Results
Intervention n = 18 | Control n = 20 | p | |
---|---|---|---|
Age (years) | 33.8 ± 3.5 | 32.5 ± 3.3 | 0.25 |
Infertility type | 6/18: Female | 4/20: Female | 0.43 |
7/18: Male | 10/20: Male | ||
2/18: Combined | 4/20: Combined | ||
2/18: Unexplained | 0/20: Unexplained | ||
Infertility duration (years) | 4.2 ± 2.2 | 5.2 ± 2.6 | 0.27 |
OCP use prior to trying for conception (years) | 4.3 ± 5.5 | 3.0 ± 4.9 | 0.46 |
Menstrual cycle length (days) | 30.8 ± 5.7 | 30.0 ± 3.8 | 0.63 |
Smoking (female) | 1/13 | 6/17 | 0.10 |
Smoking (male) | 2/12 | 5/16 | 0.66 |
Weight (kg) | 93.0 ± 16.0 | 92.1 ± 13.8 | 0.86 |
Waist circumference (cm) | 103.9 ± 10.9 | 106.8 ± 8.8 | 0.39 |
BMI (kg/m2) | 34.0 ± 4.5 | 33.9 ± 4.4 | 0.93 |
Nutrient | Pregnant | Non-Pregnant | p | Logistic Regression |
---|---|---|---|---|
Energy (kJ) | 7969.1 ± 2666.1 | 6839.0 ± 3174.1 | 0.254 | OR = 1.00, 95% CI (1.00, 1.0007) p = 0.34 |
% Protein | 20.5 ± 1.8 | 21.5 ± 4.4 | 0.369 | OR = 0.80, 95% CI (0.57, 1.12) p = 0.19 |
% Carbohydrate | 40.9 ± 5.5 | 39.8 ± 7.1 | 0.585 | OR = 1.00, 95% CI (0.84, 1.19) p = 0.98 |
% Fat | 37.4 ± 5.3 | 36.7 ± 5.5 | 0.693 | OR = 1.11, 95% CI (0.92, 1.31) p = 0.31 |
% saturated fat | 14.7 ± 2.5 | 15.5 ± 2.8 | 0.409 | OR = 0.88, 95% CI (0.64, 1.19) p = 0.40 |
% monounsaturated fat | 13.8 ± 2.2 | 13.2 ± 2.2 | 0.502 | OR = 1.54, 95% CI (0.90, 2.62) p = 0.11 |
% polyunsaturated fat | 5.7 ± 1.8 | 4.7 ± 1.1 | 0.057 | OR = 2.30, 95% CI (1.11, 4.8) p = 0.03 |
Total n3 fatty acids (g) | 1.7 ± 1.0 | 1.3 ± 0.9 | 0.167 | OR = 5.38, 95% CI (0.91, 31.78) p = 0.06 |
Total n6 fatty acids (g) | 10.4 ± 5.0 | 7.6 ± 5.0 | 0.109 | OR = 1.27, 95% CI (1.01, 1.61) p = 0.045 |
n6:n3 | 6.5 ± 2.3 | 6.3 ± 1.5 | 0.734 | OR = 1.28, 95% CI (0.77, 2.11) p = 0.34 |
GL | 101.2 ± 31.5 | 80.4 ± 32.6 | 0.061 | OR = 1.02, 95% CI (0.98, 1.05) p = 0.32 |
GI | 52.1 ± 3.6 | 49.9 ± 4.1 | 0.091 | OR = 1.32, 95% CI (0.96, 1.80) p = 0.09 |
Fibre (g) | 20.4 ± 5.8 | 17.2 ± 7.1 | 0.141 | OR = 1.08, 95% CI (0.92, 1.26) p = 0.33 |
Cholesterol (mg) | 292.0 ± 116.2 | 290.6 ± 190.7 | 0.979 | OR = 1.00, 95% CI (0.99, 1.01) p = 0.77 |
4. Discussion
5. Conclusions
Acknowledgments
Author Contributions
Conflicts of Interest
References
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Moran, L.J.; Tsagareli, V.; Noakes, M.; Norman, R. Altered Preconception Fatty Acid Intake Is Associated with Improved Pregnancy Rates in Overweight and Obese Women Undertaking in Vitro Fertilisation. Nutrients 2016, 8, 10. https://doi.org/10.3390/nu8010010
Moran LJ, Tsagareli V, Noakes M, Norman R. Altered Preconception Fatty Acid Intake Is Associated with Improved Pregnancy Rates in Overweight and Obese Women Undertaking in Vitro Fertilisation. Nutrients. 2016; 8(1):10. https://doi.org/10.3390/nu8010010
Chicago/Turabian StyleMoran, Lisa J., Victoria Tsagareli, Manny Noakes, and Robert Norman. 2016. "Altered Preconception Fatty Acid Intake Is Associated with Improved Pregnancy Rates in Overweight and Obese Women Undertaking in Vitro Fertilisation" Nutrients 8, no. 1: 10. https://doi.org/10.3390/nu8010010