Cycle Inhibiting Factors (Cifs): Cyclomodulins That Usurp the Ubiquitin-Dependent Degradation Pathway of Host Cells
Abstract
:1. Discovery and Distribution of the Cycle Inhibiting Factors (Cifs) That Triggers an Original Cytopathic Effect in Host Cells
2. Cif Proteins are Type III Effectors That Traffic to the Nucleus of the Host Cells
3. Crystal Structure Studies of Cif Homologs Reveals a Family of Proteins Sharing a Conserved Active Site
4. Cifs Are Cyclomodulins That Trigger Host Cell Cycle Arrest
5. Cif Effector Proteins Target NEDD8 to Inhibit Specific Ubiquitin-Dependent Degradation Pathways
5.1. CifEc Interacts with Host Protein NEDD8
5.2. Cif Inhibits CRL Activity
6. Concluding remarks and perspectives
References
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Taieb, F.; Nougayrède, J.-P.; Oswald, E. Cycle Inhibiting Factors (Cifs): Cyclomodulins That Usurp the Ubiquitin-Dependent Degradation Pathway of Host Cells. Toxins 2011, 3, 356-368. https://doi.org/10.3390/toxins3040356
Taieb F, Nougayrède J-P, Oswald E. Cycle Inhibiting Factors (Cifs): Cyclomodulins That Usurp the Ubiquitin-Dependent Degradation Pathway of Host Cells. Toxins. 2011; 3(4):356-368. https://doi.org/10.3390/toxins3040356
Chicago/Turabian StyleTaieb, Frédéric, Jean-Philippe Nougayrède, and Eric Oswald. 2011. "Cycle Inhibiting Factors (Cifs): Cyclomodulins That Usurp the Ubiquitin-Dependent Degradation Pathway of Host Cells" Toxins 3, no. 4: 356-368. https://doi.org/10.3390/toxins3040356